Loss of Nocturnal Decline in Blood Pressure in Diabetic Patients with Autonomic Neuropathy.
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概要
- 論文の詳細を見る
We investigated loss of the nocturnal decline in blood pressure (BP) and its mechanism in diabetes mellitus with autonomic neuropathy (ANP). BP was measured every 30min using ambulatory BP recorders in 52 diabetic patients and 11 nondiabetic controls, As an index of autonomic nervous dysfunction, CVRR (the coefficient of variation of the R-R interval on ECGs) and diastolic blood pressure response on standing were measured. Plasma volume (PV) was measured with RISA. The difference between daytime mean BP (09: 00 to 13: 00) and nighttime mean BP (01: 00 to 05: 00) was analyzed. The normal control group showed a significant reduction in mean BP during the nighttime (-12.8±7.5mmHg) as compared with the DM group (-3.3±8.6mmHg, p<0.001). The diabetic patients with loss of the nocturnal decline in blood pressure showed autonomic nervous dysfunction and increased PV. In conclusion, the nocturnal elevation of blood pressure might result from an imbalance between reduced tone of sympathetic and parasympathetic functions in addition to the postural effect and increased plasma volume present in diabetic patients.
- International Heart Journal刊行会の論文
著者
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Aoi Wataru
Department Of Biochemistry Kyoto Prefecture! University
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Nagataki Shigenobu
First Department Of Internal Medicine Nagasaki University School Of Medicine
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Ueda Yasuo
Department Of Chemistry Faculty Of Science Osaka University:osaka Titanium Co. Ltd.
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Yamachika Shiro
Department Of Cardiology Inoue Hospital
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AOI Wataru
Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital
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UEDA Yasuo
Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital
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