.BETA.3-Adrenergic Agonist Up-Regulates Uncoupling Proteins 2 and 3 in Skeletal Muscle of the Mouse.

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概要

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• Chronic stimulation of the β3-adrenergic receptor (AR) in obese animals resulted in a reduced adiposity associated with an increased expression of thermogenic uncoupling protein (UCP)1 in adipose tissues. In this study, the mRNA expression of newly cloned UCP isoforms (UCP2 and UCP3) were examined in obese yellow KK and C57BL control mice. UCP2 mRNA was found in all tissues examined, with higher levels in adipose tissues and skeletal muscle of the obese mice. UCP3 mRNA was expressed in skeletal muscle, heart and brown adipose tissue similarly in the two mouse strains. Daily injection of a selective β3-adrenergic agonist, CL316,243 (0.1 mg/kg), for 10 days resulted in a marked reduction of white fat pad weight and 1.8~4.8-fold increase in the mRNA levels of UCP2 and UCP3 in skeletal muscle of obese mice. No noticeable change in the UCP2 and 3 mRNA levels was found in brown and white adipose tissues. It was also found that CL316,243 injection produced a marked and sustained elevation of the plasma free fatty acid level. These results, together with our previous findings of the fatty acid-induced UCP expression in a myocyte cell line in vitro, suggest that the β3-AR agonist-induced UCP expression in skeletal muscle may be mediated through the elevated plasma free fatty acids. It was also suggested that anti-obesity effect of β3-AR agonists is attributable to increased thermogenesis not only by UCP1 but also by UCP2 and UCP3.

• 公益社団法人 日本獣医学会の論文

著者

• SAKANE Naoki

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• UMEKAWA Tsunekazu

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Sakane Naoki

  First Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Asano Atsushi

  Department Of Applied Chemistry National Defense Academy

• Umekawa Tsunekazu

  First Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Nagase Itsuro

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Yoshida Toshihide

  First Departmen T Of Internal Medicine Kyoto Prefectural University Of Medicine

• Sasaki Noriyasu

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Nakamura Yoshiko

  Department Of Applied Physics Faculty Of Science Science University Of Tokyo

• SAITO Masayuki

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

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