Postnatal changes in Rho and Rho-related proteins in the mouse brain
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概要
- 論文の詳細を見る
To provide information on the role of Rho, a GTP-binding protein, in postnatal development of the brain cells, the change in the levels of Rho protein and Rho-related proteins was examined in the brain of mice for two weeks after birth, in parallel with the changes in the activity of marker enzymes for neuronal and glial cells. The activities of acetylcholine esterase and choline acetyltransferase of whole brain homogenate, both of which are neuronal marker enzymes, were progressively increased in an age-dependent manner. The activity of 2', 3'-cyclic nucleotide 3'-phosphohydrolase, a glial marker enzyme, increased markedly between one and two weeks after birth. In contrast, the levels of RhoA and RhoB in the membrane fraction were decreased during the postnatal period. The amount of Rho GDP dissociation inhibitor, a regulatory protein for Rho, was unchanged, while those of Rho target proteins, Rock-2 and citron, were gradually increased. Since the inactivation of Rho is known to induce neurite extension and neuronal and glial differentiation in vitro, our results suggest that the Rho signalling pathway plays a regulatory role in the postnatal differentiation of neuronal and glial cells in vivo.
- 北海道大学の論文
- 2000-02-29
著者
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斎藤 昌之
北海道大学大学院獣医学研究科比較形態機能学講座生化学教室
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Shimada Midori
Department Of Biochemistry Faculty Of Science Nigata University
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Kimura Kazuhiro
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Kimura Kazuhiro
Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokkaido University
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Komagome R
Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokkaido University
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Komagome Rika
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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Saito Masayuki
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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Saito Masayuki
Department Of Chemistry Graduate School Of Science Osaka University
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Saito M
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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SAITO Masayuki
Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
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SAITO Masayuki
Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University
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