Plasma leptin responses to lipopolysaccharide and tumor necrosis factor α in cows
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概要
- 論文の詳細を見る
Peripheral administration of bacterial lipopolysaccharide (LPS) and various inflammatory cytokines to rodents is known to raise plasma levels of leptin, a potent satiety factor secreted from adipocytes, implying a role of leptin in endotoxin-induced anorexia. We previously reported no effect of LPS on serum leptin levels in sheep, despite marked anorexia and fever. Our results suggest that leptin might not be involved in the endotoxin-induced anorexia in ruminants. To test this idea, in the present study, plasma leptin levels were measured during acute experimental endotoxemia in Holstein cows. Intravenous injection of LPS induced anorexia accompanied with increases in plasma levels of cortisol and insulin, all of which are known to stimulate leptin secretion in rodent and human, while it did not affect plasma leptin levels at all in cows. Similar results were also obtained after injection of recombinant bovine tumor necrosis factor α. These results indicate that plasma leptin levels in cows during acute endotoxemia are differentially regulated from those in rodents, and that leptin might not be involved in the endotoxin-induced anorexia in ruminants.
- 北海道大学の論文
- 2002-11-29
著者
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石岡 克己
日本獣医生命科学大学
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Soliman Mohamed
Laboratory of Biochemistry, Department of Biomedical science, Graduate School of Veterinary Medicine
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石岡 克巳
日本獣医生命科学大学
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Saito Masayuki
日本獣医生命科学大学 獣医保健看護学科臨床部門
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Saito Masayuki
Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College
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Kimura Kazuhiro
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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Saito Masayuki
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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Kushibiki Shiro
Department of Animal Production, Tohoku National Agricultural Experimental Station
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ISHIOKA Katsumi
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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石岡 克己
Department Of Veterinary Nursing School Of Veterinary Nursing And Technology Faculty Of Veterinary S
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石岡 克己
日本獣医生命科学大学 獣医学部獣医保健看護学科
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Kushibiki Shiro
Department Of Animal Production Tohoku National Agricultural Experimental Station
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Ishioka Katsumi
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Kimura K
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Kimura Kazuhiro
Laboratorie Of Biochemistry Graduate School Of Veterinary Medicine Hokkaido University
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Saito Masayuki
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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