Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cells

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概要

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• We examined the effect of stroma-derived factors, hepatocyte growth factor（HGF）and leptin, on morphological differentiation of bovine mammary epithelialcells（BMEC）in collagen gel three-dimensional culture in vitro. BMECtreated with HGF, but not leptin, formed duct-like organoids. The formation oforganoids by HGF was enhanced by treatment with a mixture of insulin, cortisoland prolactin, while BMEC treated with the mixture alone did not producethe organoid. In contrast, the formation of organoids by HGF was dosedependentlyinhibited by simultaneous addition of leptin, regardless of thepresence or absence of the hormone mixture . These results suggest thatstroma-derived factors intricately regulate mammary epithelial morphogenesis.

• The Graduate School of Veterinary Medicine, Hokkaido Universityの論文
• 2007-02-28

著者

• アハメド モハメド

  北海道大学大学院獣医学研究科生化学教室

• Saito Masayuki

  日本獣医生命科学大学 獣医保健看護学科臨床部門

• Saito Masayuki

  Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College

• Makondo K

  Hokkaido Univ. Sapporo

• Kimura K

  Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine

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