HYPERPLASIA OF BROWN ADIPOSE TISSUE AFTER CHRONIC STIMULATION OF β3-ADRENERGIC RECEPTOR IN RATS

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概要

• 論文の詳細を見る

• When mammals are exposed to a cold environment for a long time, the capacity of nonshivering thermogenesis by brown adipose tissue (BAT) increases in association with the increased expression of some specific proteins and tissue hyperplasia, which are totally dependent on sympathetic innervation to this tissue. To clarify roles of the β-adrenergic mechanism in BAT hyperplasia, the effects of chronic administration of various β-adrenergic agonists on BAT were examined in rats, especially focusing on some agonists to the β3-adrenoceptor which is present specifically in adipocytes. Chronic administration of noradrenaline or isoproterenol for 7-10 days produced a marked increase in the tissue contents of DNA, total protein, mitochondrial uncoupling protein, and insulinregulatable glucose transporter protein. The trophic effects of noradrenaline and isoproterenol were mimicked by chronic administration of β3-adrenergic agonists, such as CL316,243,BRL 26830A, and ICI D7114. These results suggest that the β3-adrenoceptor plays important roles for hyperplasia of BAT, and thereby increasing in the capacity of thermogenesis.

• 北海道大学の論文
• 1995-01-31

著者

• SAITO Masayuki

  Department of Environmental and Molecular Bio-Informatics, Kanazawa University School of Medicine

• YOSHIDA TOSHIHIDE

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Saito Masayuki

  日本獣医生命科学大学 獣医保健看護学科臨床部門

• Tanaka Kyoko

  Department Of Obstetrics And Gynecology School Of Medicine Keio University

• Morimatsu M

  Iwate Univ. Morioka Jpn

• NAGASE Itsuro

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

• SASAKI Noriyasu

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

• TSUKAZAKI Katsumi

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

• MORIMATSU Masami

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

• Saito Masayuki

  Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College

• Tsukazaki Katsumi

  Department Of Obstetrics And Genecology National Defense Medical College

• Nagase Itsuro

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Yoshida Toshihide

  First Departmen T Of Internal Medicine Kyoto Prefectural University Of Medicine

• Tsukazaki Katsumi

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Sasaki Noriyasu

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Morimatsu Masami

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Saito Masayuki

  Department Of Chemistry Graduate School Of Science Osaka University

• SAITO Masayuki

  Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University

• SAITO Masayuki

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

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