Biological Characteristics of Human Uterine Endometrial Cancer Variant Cells Selected for Blood Group H Type 1 Antigen : Adhesion to Vascular Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
The expression level of Lewis^b(Le^b)antigen was previously shown to correlate with the five-year survival rate of human endometrial cancer patients. Variant cell lines with high(SNG-S)and low(SNG-W)levels of cell surface Le^b antigen were isolated from the heterogeneous endometrial cancer cell line SNG-II cells to characterize the biological significance of Le^b antigen on endometrial cancer cells. SNG-S cells mainly expressed Le^b, whereas SNG-W cells mainly expressed H type 1 carbohydrate antigen alternatively. In an in vitro system, SNG-W cells showed a greater capacity to adhere to cytokine-activated human umbilical vein endothelial cells. Their adhesion to human umbilical vein endothelial cells was partially inhibited by pretreatment of antibody specific for H type 1 carbohydrate antigen. These results suggested that the H type 1 carbohydrate antigen expressed on endometrial cancer cells is involved in the adhesion to endothelial cells.
- 日本組織細胞化学会の論文
著者
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NAKAMURA Seigo
Breast Center
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NOZAWA Shiro
Department of Obstetrics and Gynecology, School of Medicine, Keio University
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Yamashita Hiroshi
Department Of Otolaryngology Yamaguchi University Graduate School Of Medicine
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Nozawa S
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Nozawa Shiro
Department Of Obstetrics And Gynecology Keio School Of Medicine
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Tanaka Kyoko
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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TSUKAZAKI Katsumi
Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University
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Yamamoto H
Life Science Development Center Cpi Company Daicel Chemical Industries Ltd. Tsukuba Research Center
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Kubushiro Kaneyuki
Department of Obstetrics and Gynecology, Toho University Ohashi Medical Center
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BANNO Kouji
Department of Obstetrics and Gynecology, Keio University School of Medicine
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Kiguchi Kazushige
G Hosp
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Yamamoto Hiroaki
Life Science Development Center Cpi Company Daicel Chemical Industries Ltd. Tsukuba Research Center
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Banno Kouji
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Tsukazaki Katsumi
Department Of Obstetrics And Genecology National Defense Medical College
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Yamashita Hiroshi
Department Of Cardiovascular Medicine The University Of Tokyo
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Yamashita H
Mathematical Systems Inc.
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Nozawa Shiro
Breast Center
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FUKUCHI Takeshi
Department of Obstetrics and Gynecology, Keio University, School of Medicine
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Sakuma Yuichi
Department of Obstetrics and Gynecology, School of Medicine, Keio University
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Tsukazaki Katsumi
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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Kiguchi K
Department Of Obstetrics And Gynecology St. Marianna University School Of Medicine
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Kubushiro Kaneyuki
Department Of Obstetrics And Gynecology Kawasaki Municipal Hospital
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Kiguchi Kazushige
Department Of Obstetrics And Gynecology Tokyo Hospital St. Marianna University School Of Medicine
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Fukuchi Takeshi
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Sakuma Yuichi
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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Yamashita Hiroshi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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