The free radical scavenger edaravone protects hair cells against aminoglycoside toxicity
スポンサーリンク
概要
- 論文の詳細を見る
Reactive oxygen species are involved in inner ear hair cell death induced by aminoglycosides. Therefore, inhibition of free radicals can prevent hair cell death. The antioxidant, edaravone has been used clinically in Japan. In this study, we evaluated whether edaravone can protect hair cells against aminoglycoside-induced cytotoxicity in cultured mouse utricles. Utricles from CBA/N mice were cultured in medium containing neomycin alone (1 mM), or neomycin plus edaravone. Hair cells cultured with neomycin alone were damaged after 24 hours. Survival of hair cells cultured with neomycin plus edaravone (30 or 100 μM) was significantly greater than that of hair cells cultured with neomycin alone. Immunohistochemistry showed the production of 4-hydroxy-2-nonenal in utricles cultured with neomycin but not in utricles cultured with neomycin plus edaravone (100 μM). These results suggest that the inhibibion of reactive oxygen species production by edaravone protects hair cells. In addition, high concentrations of edaravone did no show cytotoxicity.
- Yamaguchi University School of Medicineの論文
著者
-
Yamashita Hiroshi
Department Of Otolaryngology Yamaguchi University Graduate School Of Medicine
-
Sugahara Kazuma
Department Of Otolaryngology Yamaguchi University Graduate School Of Medicine
-
Shimogori Hiroaki
Department Of Otolaryngology Yamaguchi University Graduate School Of Medicine
関連論文
- Effects of lectin in the scleractinian coral Ctenactis echinata on symbiotic zooxanthellae
- RSウイルス感染症に併発する急性中耳炎の臨床的特徴
- The free radical scavenger edaravone protects hair cells against aminoglycoside toxicity
- Load dependence of calcium transient of a single cardiac myocyte revealed by a novel force-calcium measurement system
- OE-202 Chronic Inflammation, Macrophage Recruitment and CD8+ T Cell Activation in Obese Adipose Tissue Visualized by in vivo Molecular Imaging(OE35,Metabolic Syndrome (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circu
- OE-013 Platelet Kinetics in Thrombus Formation, and Inflammatory Status Revealed by in Vivo Molecular Imaging(OE03,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- Adrenomedullin, an Autocrine Mediator of Blood-Brain Barrier Function
- Detection of Adsorbed Hydrogen on W(001) by Using ^1H(^N,αν)^C Reaction
- FRS-022 Adipogenesis in Obesity Requires Interplay between Differentiating Adipocytes, Stromal Cells and Blood Vessels(Diabetes/Obesity (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Myosin light chain isoforms modelate motor function of cardiac myosin by altering crossbridge kinetics
- Protein Kinase A Increases the Rate of Relaxation but Not the Rate of Tension Development in Skinned Rat Cardiac Muscle
- APPLICATION OF ULTRATHIN CRYO-SECTIONS TO ENZYME HISTOCHEMISTRY (Histo- and Cytochemistry in Tissue Culture)
- OE-134 Responses of Single Ventricular Myocytes to Dynamic Axial Stretching(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-120 Close Relationships between Angiogenesis and Adipogenesis in Obesity Revealed by a Novel Visualization Technique of Living Adipose Tissue(Diabetes/Obesity/Metabolic syndrome-1 (H) OE20,Oral Presentation (English),The 70th Anniversary Annual Scienti
- Contractile Dysfunction of the Cardiomyopathic Hamster (BIO-TO2 Strain) Myocytes in Pronounced under High Load Conditions(Cardiac Function, Basic/Clinical 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Microtubules Modulate the Mechanical Property of Isolated Rat Cardiomyocytes Only against the Shear Stress in Long Axis Direction(Cardiac Function, Basic/Clinical 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Measurement of Transverse Stiffness during Contraction and Relaxation of a Single Cardiomyocyte(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Carbocyl-terminal Fragment of Myosin Light Chain Kinase Increases Actin Translocation Velocity without Altering ATPase Activity or Unltary Displacement(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation
- Myosin Subfragment-2 (S-2) is Important for the Motor Function of the Molecule(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-197 Single Cell Mechanics of Cardiomyocytes under Isometric, Unloaded and Physiologically Loaded Conditions(Cardiac Function, Basic/Clinical 1 (M) : OE24)(Oral Presentation (English))
- FRS-017 Carboxyl terminal region of myosin light chain kinase increases actin translocation velocity without altering ATPase activity(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
- Effects of Aging and Denervation on the Expression of Uncoupling Proteins in Slow- and Fast-Twitch Muscles of Rats
- Photoreactions in ^Si Nucleus by Monochromatic Gamma-Rays
- Combustion Technology in a Novel Gas Turbine System with Steam Injection and Two-Stage Combustion
- Molecular physiology, a novel approach to cardiac fucntion
- Application of Real-Time Confocal Microscopy to Observations of ATP-Induced Ca^-Oscillatory Fluctuations in Intact Corneal Epithelial Cells (Mini-SymposiumCurrent Topics in Cell Biology : From Molecules to Tissues)
- Synthesis of Terphenylboronic Acid Derivatives and Recognition of Anomers of 2-Deoxyribofuranoside
- Microvasucular architecture in two distinct gingival regions divided by an accumulation of dental calculus
- Postnatal depression in Japanese mothers and the reconsideration of "Satogaeri bunben"
- B13-118 NEAR EXTINCTION FLAME STRUCTURE OF MICRO-DIFFUSION FLAMES
- Upregulation of synapsin IIa and IIb mRNAs in the paraventricular and supraoptic nuclei in chronic salt loaded and lactating rats
- Does Recurrent Inhibition Exist in the Paraventricular Magnocellular Neurosecretory Cells in the Male Rat?
- Gonadotropin-Releasing Hormone Analogue Therapy for Peritoneal Inclusion Cysts after Gynecological Surgery
- Biological Characteristics of Human Uterine Endometrial Cancer Variant Cells Selected for Blood Group H Type 1 Antigen : Adhesion to Vascular Endothelial Cells
- Biological Function of Type1 Carbohydrate Antigen in Endometrial Cancer
- A High Activity of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in Chloroplasts of Stevia rebaudiana Bertoni
- Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux : study by 24-h pH monitoring in patients with gastric or duodenal ulcer
- Displacement of Acid Phosphatase and Alkaline Phosphatase Proteins in the Rat Kidney during a Dehydration Procedure : An Advantage of Ultrathin Frozen Sections for Detecting Precise Localization of an Enzyme Activity
- Precipitate-forming Reaction of β-(1→4)-D-Glucanase(I) in Malt(Biological Chemistry)
- Clinical Evaluation of Polymerase Chain Reaction DNA Amplification Method for the Diagnosis of Pulmonary Tuberculosis in Patients with Negative Acid-fast Bacilli Smear
- Topical application of substance P facilitates vestibular functional recovery induced by AMPA in the guinea pig