A High Activity of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in Chloroplasts of Stevia rebaudiana Bertoni

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概要

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• Stevia leaves (Stevia rebaudiana Bertoni; Compositae) accumulate sweet glycosides, the aglycone of which is a diterpene derivative, steviol. The activity of the rate-limiting enzyme of the isoprenoid pathway leading to steviol, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was found to be extremely (over 150-fold in the specific activity) higher in chloroplasts of stevia leaves than the activity of Spinacia oleracea and about 10-fold higher than that of Solidago altissima L., which also belongs to the Compositae family. There was no difference in apparent K_m values for HMG-CoA and inhibitionis by mevastatin between the activities of thylakoid membranes from S. rebaudiana and S. altissima L. Those activities were almost the same level in microsomal fractions of the three plant leaves.

• 社団法人日本農芸化学会の論文
• 1996-04-23

著者

• KIM Keun

  Department of Neurosurgery, Yongdong Severance Hospital, Yonsei University College of Medicine

• Yamashita Hiroshi

  Department Of Otolaryngology Yamaguchi University Graduate School Of Medicine

• Kim Keun

  Life And Environ. Science Shimane Univ.

• SHIBATA Hitoshi

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane Uni

• SAWA Yoshihiro

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane Uni

• Sawa Yoshihiro

  Life And Environ. Science Shimane Univ.

• Yamashita Hiroshi

  Department Of Cardiovascular Medicine The University Of Tokyo

• Kim Keun

  Department Of Neurosurgery And Institute Of Spine And Spinal Cord Yongdong Severance Hospital Yonsei

• Sawa Yoshihiro

  Department Of Life Science And Biotechnology Shimane University

• YAMASHITA Hiroshi

  Life and Environ. Science, Shimane Univ.

• Shibata Hitoshi

  Life And Environ. Science Shimane Univ.

• Kim Keun

  Department Of Bioscience And Biotechnology The University Of Suwon

• Shibata Hitoshi

  Department Of Applied Biological Science Faculty Of Agriculture Shimane University

• Yamashita Hiroshi

  Life And Environ. Science Shimane Univ.

• Sawa Yoshihiro

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• Sawa Yoshihiro

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane University

• Yamashita Hiroshi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• SHIBATA Hitoshi

  Department of Agricultural Chemistry, Faculty of Agriculture, Shinshu University

• KIM Keun

  Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea

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