Iron Chelation by Chlorogenic Acid as a Natural Antioxidant

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概要

• 論文の詳細を見る

• Chlorogenic acid, a dietary antioxidant, effectively inhibited the iron-induced lipid peroxidation of bovine liver microsomes in a concentration-dependent manner. In the Fenton-type reaction, chlorogenic acid inhibited the production of the hydroxyl radical by iron-EDTA or iron-ADP, while iron plus chlorogenic acid did not generate the hydroxyl radical. The formation of an iron complex with chlorogenic acid was demonstrated by UV/vis absorbance spectroscopic, ESR and ^1H-NMR studies. The ferric complex with chlorogenic acid was in the ferric high-spin state near rhombicity, and had no radical scavenging activity. The results indicate that chlorogenic acid prevented the formation of the hydroxyl radical by forming a chelate with iron whose complex cannot catalyze the Fenton-type reaction.

• 社団法人日本農芸化学会の論文
• 1998-01-23

著者

• SAKAMOTO Yuji

  Department of Aerospace Engineering, Tohoku University

• KONO Yasuhisa

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane Uni

• SHIBATA Hitoshi

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane Uni

• Kono Yasuhisa

  Department Of Bacteriology Faculty Of Medicine Tottori University

• Sakamoto Y

  Nihon Univ. Kanagawa Jpn

• KASHINE Sakiko

  Department of Life Science and Biotechnology Faculty of Life and Environmental Science Shimane Unive

• YONEYAMA Takushi

  Department of Life Science and Biotechnology Faculty of Life and Environmental Science Shimane Unive

• MATSUI Yoshihisa

  Department of Life Science and Biotechnology Faculty of Life and Environmental Science Shimane Unive

• Sakamoto Yuji

  Department Of Aeronautics And Astronautics

• Shibata H

  Dept. Life Environ. Sci. Shimane Univ.

• Sawa Yoshihiro

  Dept. Life Environ. Sci. Shimane Univ.

• Kono Y

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• Sawa Yoshihiro

  Dept. Appl. Biosci. And Biotech. Fac. Life And Environ. Sci. Shimane Univ.

• Sakamoto Yoko

  Department Of Food Science And Technology College Of Bioresouce Sciences Nihon University

• Shibata Hitoshi

  Department Of Applied Biological Science Faculty Of Agriculture Shimane University

• Yoneyama Takushi

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• Matsui Y

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• SHIBATA Hitoshi

  Department of Agricultural Chemistry, Faculty of Agriculture, Shinshu University

• Matsui Yoshihisa

  Department of Agricultural Chemistry, Faculty of Agriculture, Shimane University

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