Pharmaceutical Evaluation of Metronidazole Ointments for Cancerous Malodor Prepared in a Hospital

概要

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Metronidazole (MTZ) ointments, which are indispensable in the treatment of cancerous malodor, are not yet commercially available at pharmacies in Japan. In view of this, we prepared two MTZ preparations, MTZ-Hydrophilic ointment (MTZ-Oint) and MTZ-Carbopol^[○!R] gel (MTZ-Gel), and supplied them to patients at St. Luke's International Hospital. MTZ preparations should be preferably soft and easy to spread in order to be applied to cancerous skin ulcers. We therefore conducted a sensory evaluation of the spreadability, viscosity, usability and other aspects of the texture of MTZ-Oint and MTZ-Gel with the help of nurses taking care of the patients. Both MTZ-Oint and MTZ-Gel were adequate in terms of softness and spreadability, although MTZ-Gel was better in these respects than MTZ-Oint. We also examined the stability of the MTZ preparations under several storage conditions, finding that MTZ-Oint was stable under all of the storage conditions but MTZ-Gel had to be kept at room temperature in order to preserve its appearance and quality. These findings should be invaluable in the development of more effective preparations in the future.
日本医療薬学会の論文
2008-05-10