Effect of Islet-Activating Protein (IAP) Upon Insulin Secretion from Human Pancreatic Islets

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概要

• 論文の詳細を見る

• A new protein termed islet-activating protein (IAP) has recently been extracted from the culture medium of Bordetella pertussis, and shown to enhance insulin secretion either <I>in vivo</I> in rats or <I>in vitro</I> in isolated pancreatic islets due to activation of native calcium ionophores. However, it has not been clarified whether or not IAP enhances the secretion of insulin in human pancreatic islets. In order to examine the effect of IAP on human pancreatic islets, pancreatic tissues were obtained from seven patients who had appeared normal in a glucose tolerance test prior to pancreatectomy. Insulin secretion was significantly increased in IAP treated pancreatic islets by the glucose and the arginine stimuli. It is concluded that IAP enhances the insulin secretion in response to insulin secretagogues in human pancreatic islets, suggesting the possible clinical application of IAP to diabetic patients.

• 社団法人 日本内分泌学会の論文

著者

• Kondo Motoharu

  First Department Of Internal Medicine Department Of Radiology Kyoto Prefectural University Of Medici

• NAKAMURA Naoto

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• NAKANO Koji

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshida Toshihide

  First Departmen T Of Internal Medicine Kyoto Prefectural University Of Medicine

• ARAKI YOSHIMASA

  First Department of Internal Medicine, Kyoto Prefectural University

• KOYAMA KATSUSHI

  First Department of Internal Medicine, Kyoto Prefectural University

• NAKAMURA YOSHIO

  First Department of Internal Medicine, Kyoto Prefectural University

• NAKAMURA NAOTO

  First Department of Internal Medicine, Kyoto Prefectural University

• YOSHIDA TOSHIHIDE

  First Department of Internal Medicine, Kyoto Prefectural University

• NAKANO KOJI

  First Department of Internal Medicine, Kyoto Prefectural University

• KONDO MOTOHARU

  First Department of Internal Medicine, Kyoto Prefectural University

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