Serum Concentrations of Δ5-3β-Hydroxysteroids in Type 2 Diabetes Mellitus

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概要

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• We examined the serum concentrations of Δ5-3β-hydroxysteroids, pregnenolone (Preg), 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA), androstenediol (ADIOL) and their sulfates in 30 well controlled (Group I: HbA1c<7.0%) and 15 poorly controlled (Group II: HbA1c>7.1%) type 2 diabetic patients, and 30 normal controls. These patients were treated with diet therapy or anti-diabetic agent. The distribution of gender and age of the subjects were matched between the groups. The serum levels of sulfo-conjugated and unconjugated steroids described above were measured by GC-MS and enzyme immunoassay (EIA), respectively. The serum levels of the entire sulfo-conjugated steroid measured in this study were significantly lower in Groups I and II than in controls. On the other hand, Preg levels in both Groups I and II were significantly higher than those in controls, whereas the serum levels of the downstream unconjugated steroids were not different from controls. To investigate the effect of sulfonylurea (SU) on the serum levels of steroids, the serum concentrations of steroids between the patients who were treated with diet therapy and SU agent were compared in Group I. No significant differences were observed between both groups. These results suggest that (1) since increased Preg levels did not cause any changes in the downstream Δ5-3β-hydroxysteroid levels, the metabolic pathway of Δ4-3-ketosteroids may be accelerated in type 2 diabetes; (2) serum steroid levels were not affected by SU treatment; (3) sulfo-conjugated steroid catabolism was altered in type 2 diabetes; (4) the decreased sulfo-conjugated steroids especially ADIOLS may contribute to the alteration of sex steroid levels and onset or exacerbate infectious diseases in diabetes.

著者

• Nakamura Naoto

  Kyoto Prefectural Univ. Medicine Kyoto Jpn

• NAKAMURA Naoto

  Division of Biochemistry and Immunochemistry National Institute of Health Sciences

• Ohta Mitsuhiro

  Clinical Chemistry Laboratory Kobe Pharmaceutical University

• Okita Mika

  Department Of Molecular Gastroenterology & Hepatology Kyoto Prefectural University Graduate Scho

• Nakano Koji

  Department Of Cardiology And Internal Medicine Yamashiro Public Hospital

• Obata Hirozumi

  Departments Of Gastroenterology And Hepatology Saiseikai Suita Hospital

• Kobayashi Yoshiharu

  Clinical Chemistry And Medicinal Chemistry Laboratories Kobe Women's College Of Pharmacy

• Kobayashi Yoshiharu

  Clinical Chemistry Laboratory Kobe Pharmaceutical University

• TAGAWA Noriko

  Clinical Chemistry Laboratory

• NAKAMURA Naoto

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• NAKANO Koji

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• OBAYASHI Hiroshi

  Kyoto Microbiological Institute

• Nakamura Naoto

  Department Of Endocrinology And Metabolism Kyoto Prefectural University Of Medicine Graduate School

• Nakano K

  First Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• OBAYASHI Hiroshi

  Department of Molecular Biochemistry, Institute of Bio-Response Informatics

• Ose Hiroyuki

  Department Of Molecular Biochemistry Institute Of Bio-response Informatics

• NAKAMURA NAOTO

  First Department of Internal Medicine, Kyoto Prefectural University

• NAKANO KOJI

  First Department of Internal Medicine, Kyoto Prefectural University

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