Normalization of Blood Glucose in Totally Pancreatectomized Dogs by Use of Pancreatic Chambers

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概要

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• Two ancreaticp chambers constructed of plastic tube and ultrafiltration membrane and containing the minced pancreases of five neonatal rats were implanted in the omentum of totally pancreatectomized diabetic dogs. Blood glucose levels in the diabetic dogs leveled off just after operation, in contrast with those in control animals, in which vacant chambers were implanted, and began to decrease about a week after the transplantation. Blood glucose levels fell to less than 150mg/100m<I>l</I> within three weeks. The neonatal rat pancreases in the pancreatic chamber produced a near normal plasma glucose and insulin response to an intravenous glucose tolerance test on the 20th day after transplantation. Removal of the pancreatic chamber from the experimental dogs after normalization of blood glucose levels, caused a rapid elevation of blood glucose levels, and lead to death within four days. No rejection reactions were observed in the course of the experiment. These findings suggest that pancreatic transplantation with the pancreatic chamber is potentially useful for the treatment of diabetes.

• 社団法人 日本内分泌学会の論文

著者

• Kondo Motoharu

  First Department Of Internal Medicine Department Of Radiology Kyoto Prefectural University Of Medici

• Yoshida Toshihide

  First Departmen T Of Internal Medicine Kyoto Prefectural University Of Medicine

• ARAKI YOSHIMASA

  First Department of Internal Medicine, Kyoto Prefectural University

• NAKAMURA YOSHIO

  First Department of Internal Medicine, Kyoto Prefectural University

• YOSHIOKA KUNINORI

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• INOUE YASUNORI

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

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