Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells
スポンサーリンク
概要
- 論文の詳細を見る
Endothelial cells are important for maintenance of vascular integrity by producing a variety of bioactive molecules such as nitric oxide (NO). Recent evidence has suggested that there are some differences in characteristics between endothelial cells from different origins. Here we examined responses of two typical endothelial cells to hepatocyte growth factor (HGF), which induces endothelium-dependent relaxation of microvessels. Stimulation of human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells (BAEC) with HGF increased endothelial NO synthase activity, accompanied with an increase of activity-related site-specific phosphorylation of protein kinase B/Akt. However, HGF stimulated phosphorylation of p38 mitogen-activated protein kinase (MAPK) only in HUVEC, but not in BAEC, while it, induced phosphorylation of p44 /p42 MAPK in both cells. These results suggest that HGF transduces different intracellular signals between aortic and umbilical venous endothelial cells, and that the differences might represent divergent endothelial responses to growth factors, especially those that activate receptor-tyrosine kinases.
- 北海道大学の論文
- 2003-08-29
著者
-
Saito Masayuki
日本獣医生命科学大学 獣医保健看護学科臨床部門
-
Saito Masayuki
Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College
-
Makondo Kennedy
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
-
Kimura Kazuhiro
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
-
Kitamura Takanori
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
-
Yamaji Daisuke
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
-
Saito Masayuki
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
-
Makondo K
Hokkaido Univ. Sapporo
-
Kitamura Takanori
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
-
Kimura K
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
-
Kimura Kazuhiro
Laboratorie Of Biochemistry Graduate School Of Veterinary Medicine Hokkaido University
-
Saito Masayuki
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
関連論文
- Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cells
- Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype
- Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats
- Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA 98 elicited by benzo［a］pyrene and oxidative DNA lesions in V 79 hamster lung cells
- Acute and Chronic Regulation of ob mRNA Levels by β_3-Adrenoceptor Agonists in Obese Yellow KK Mice
- ラット褐色脂肪組織における血管新生因子mRNAの発現と寒冷暴露による増加
- Retinol binding protein 4 in dairy cows : its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period
- HYPERPLASIA OF BROWN ADIPOSE TISSUE AFTER CHRONIC STIMULATION OF β3-ADRENERGIC RECEPTOR IN RATS
- Serum Leptin Levels during the Periparturient Period in Cows
- Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes
- Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cells
- Effects of leptin and tumor necrosis factor-alpha on degranulation and superoxide production of polymorphonuclear neutrophils from Holstein cows.
- Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and expression analysis in the mammary gland
- Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells
- Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells
- Norepinephrine Stimulates Interleukin-6 mRNA Expression in Primary Cultured Rat Hepatocytes^1
- cDNA Cloning of Nuclear Localization Signal Binding Protein NBP60, a Rat Homologue of Lamin B Receptor, and Identification of Binding Sites of Human Lamin B Receptor for Nuclear Localization Signals and Chromatin^1
- Feline Adiponectin: Molecular Structures and Plasma Concentrations in Obese Cats(Biochemistry)
- Conjugated Linoleic Acid Deteriorates Insulin Resistance in Obese/Diabetic Mice in Association with Decreased Production of Adiponectin and Leptin
- Adrenocortical responses to tumor necrosis factor-α and interferon-γ in cattle
- Plasma leptin responses to lipopolysaccharide and tumor necrosis factor α in cows
- Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
- Expression of β3-Adrenoceptor and Stimulation of Glucose Transport by β3-Agonists in Brown Adipocyte Primary Culture^1
- Chronic administration of β-Adrenergic Agonists Can Mimic the Stimulative Effect of Cold Exposure on Protei Synthesis in Rat Brown adipose Tissue
- The expression of src-suppressed C kinase substrate (SSeCKS) and uptake of exogenous particles in endothelial and reticular cells
- Bacterial lipopolysaccharide-induced expression of the IκB protein MAIL in B-lymphocytes and macrophages
- CONFIRMED NUCLEOTIDE SEQUENCE OF fanF OF ESCHERICHIA COLI K99 FIMBRIAE
- N-(Benyloxycarbony)-L-Aspartyl-L-Phenylalanine Methyl Ester Production by Immobilized Nocardia opaca : Thermolysin under Hydrogen High Pressure in a Water-Organic Solvent System
- 219 L-Phenylalanine Methyl Ester Production from Phenylpyruvate Methyl Ester by Immobilized Cells Under Hydrogen High Pressure in Water-Organic Solvent System.
- Purification and Structure of Novel Cysteine Proteinase Inhibitors, Staccopins P1 and P2, from Staphylococcus tanabeensis(Biological Chemistry)
- Experimental and Clinical Studies on Plasma Leptin in Obese Dogs
- 319 Continual L-Phenylalanine Production from Phenylpyruvate by Immobilized Cells of Nocardia Opaca Under Hydrogen High Pressure
- Possible involvement of uncoupling protein 1 in appetite control by leptin
- Proinsulin C-peptide Induces Phosphorylation of Mitogen-Activated Protein Kinases (MAPK) in Swiss 3 T 3 and 3 T 3-F442A Cells
- Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes
- Postnatal changes in Rho and Rho-related proteins in the mouse brain
- Laboratory of Biochemistry (An Introduction of the four Departments composing the Graduate Scholl of Veterinary Medicine, Hokkaido University (2))
- No Alteration in Serum Leptin Levels during Acute Endotoxemia in Sheep.
- Quantitative Changes in Serum Concentration of Bovine Gut Chitinase in Theileria Infection
- Expression of .BETA.3-Adrenoceptor and Stimulation of Glucose Transport by .BETA.3-Agonists in Brown Adipocyte Primary Culture.