No Alteration in Serum Leptin Levels during Acute Endotoxemia in Sheep.
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概要
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To determine the role of leptin in endotoxin-induced anorexia in ruminants, circulating leptin levels were measured during acute experimental endotoxemia in sheep. Injection of bacterial lipopolysaccharide (450 ng/kg, i.v.) induced anorexia accompanied with fever and increases in serum levels of cortisol, insulin and glucose which are known to stimulate leptin secretion in rodent and human, while it did not affect serum leptin levels at all. These results indicate that serum leptin levels in sheep during acute endotoxemia are differentially regulated from those in rodent and human, and that leptin might not be involved in the endotoxin-induced anorexia in sheep.
- 公益社団法人 日本獣医学会の論文
著者
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Soliman Mohamed
Laboratory of Biochemistry, Department of Biomedical science, Graduate School of Veterinary Medicine
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ABDELHADY Shawky
Department of Biochemistry & Physiology, Faculty of Veterinary Medicine, Tonta University
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Kitamura Hiroshi
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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Ishioka Katsumi
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Kimura Kazuhiro
Laboratorie Of Biochemistry Graduate School Of Veterinary Medicine Hokkaido University
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Saito Masayuki
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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ABDELHADY Shawky
Department of Biochemistry & Physiology, Faculty of Veterinary Medicine, Tanta University
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FATTOUH Ibrahem
Department of Biochemistry & Physiology, Faculty of Veterinary Medicine, Tanta University
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SOLIMAN Mohamed
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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ISHIOKA Katsumi
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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