Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
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概要
- 論文の詳細を見る
Interleukin (IL)-6, a cytokine for host defense responses to infection and imflammation, is known to be induced by non-invasive physical or psychological stress, too. To test possible involvement of brain IL-1 in the stress-induced IL-6 production, IL-1 mRNA expression in the hypothalamus, in parallel with blood IL-6 level, was examined in rats subjected to restriction of their movement (immobilization stress). When rats were immobilized, the hypothalamic IL-1β mRNA level was increased in 1 hr, followed by progressive rises in the serum IL-6 level. The immobilization-induced rise in serum IL-6 was mimicked by intracerebroventricular (icv) administration of IL-1β under normal conditions, whereas it was attenuated by icv injection of an IL-1 receptor antagonist. These results indicate that IL-1 in the hypothalamus plays a pivotal mediating role in the stress-induced peripheral IL-6 production.
- 北海道大学の論文
- 2001-05-31
著者
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Saito Masayuki
日本獣医生命科学大学 獣医保健看護学科臨床部門
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Saito Masayuki
Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College
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Kimura Kazuhiro
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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Saito Masayuki
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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Kitamura Hiroshi
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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ISHIKAWA Ikuyo
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicin
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Ishikawa Ikuyo
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Kimura K
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Kimura Kazuhiro
Laboratorie Of Biochemistry Graduate School Of Veterinary Medicine Hokkaido University
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Saito Masayuki
Laboratories Of Biochemistry Department Of Biomedical Sciences Hokkaido University Graduate School O
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