Conjugated Linoleic Acid Deteriorates Insulin Resistance in Obese/Diabetic Mice in Association with Decreased Production of Adiponectin and Leptin

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概要

• 論文の詳細を見る

• Dietary supplementation of conjugated linoleic acids (CLA) is known to have some beneficial effects such as anti-carcinogenic and anti-obesity effects in several animal species, while it also induces insulin resistance and fatty liver, especially in mice. To explore the possible factors responsible for the CLA-induced insulin resistance, we examined the plasma and mRNA expression levels of several adipocytokines, which are likely involved in the regulation of insulin sensitivity, in normal C57BL, mildly obese/diabetic KK and morbidly obese/diabetic KKAy mice. Feeding a diet supplemented with 0.5% CLA oil consisting of 30.5% c9, t11-CLA and 28.9% t10, c12-CLA for 4 wk resulted in a decrease in white adipose tissue (WAT), an increase in liver weight with excess accumulation of triglyceride, and insulin resistance associated with hyperglycemia and hyperinsulinemia. The plasma and WAT mRNA levels of leptin were higher in KK and KKAy mice than C57BL mice, whereas those of adiponectin were higher in C57BL mice. CLA-feeding decreased the levels of leptin, adiponectin and resistin, especially in KK and KKAy mice. In contrast, tumor necrosis factor-α (TNFα) mRNA levels were higher in KK and KKAy mice than C57BL mice, and were increased by CLA feeding. The present results thus indicate that CLA feeding promotes insulin resistance in obese/diabetic mice by at least inverse regulation of leptin and adiponectin, and TNFα, adipocytokines known to either ameliorate or deteriorate insulin sensitivity, respectively.

• 日本ビタミン学会の論文

著者

• SHIBATA Haruki

  Morinaga Institute of Biological Science, Inc.

• SAITO Masayuki

  Department of Environmental and Molecular Bio-Informatics, Kanazawa University School of Medicine

• Saito Masayuki

  日本獣医生命科学大学 獣医保健看護学科臨床部門

• KIMURA Kazuhiro

  Department of Respiratory Medicine, Toho University Medical Center

• MIYASHITA Kazuo

  Department of Bioresources Chemistry, Graduate School of Fisheries Science, Hokkaido University

• OHASHI Atsuko

  Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences Universit

• Ohashi Atsuko

  Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science

• Saito Masayuki

  Department Of Nutrition Graduate School Of Nursing And Nutrition Tenshi College

• Shibata Haruki

  Morinaga Institute Of Biological Sciences

• MATSUSHITA Yukiko

  Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• Kimura Kazuhiro

  Department Of Cardiology Maizuru Kyosai Hospital

• Miyashita Kazuo

  Department Of Bioresources Chemistry Graduate School Of Fisheries Sciences Hokkaido University

• Kimura K

  Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine

• Kimura Kazuhiro

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University

• Miyashita Kazuo

  Department Of Bioresources Chemistry Graduate School Of Fisheries Science Hokkaido University

• Saito Masayuki

  Department Of Chemistry Graduate School Of Science Osaka University

• Matsushita Yukiko

  Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokkaido University

• Miyashita Kazuo

  Department Of Bioengineering Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Technology

• SAITO Masayuki

  Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University

• SAITO Masayuki

  Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University

• SHIBATA Haruki

  Morinaga Institute of Biological Science

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