Molecular Cloning and Tissue Distribution of Uncoupling Protein 1 (UCP1) in Plateau Pika (Ochotona dauurica)
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概要
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Uncoupling protein 1 (UCP1) is present exclusively in brown adipose tissue, and contributes to body temperature control during cold exposure. We cloned UCP1 cDNA of plateau pika (Ochotona dauurica), a small, non-hibernating, diurnal lagomorph that inhabits in relatively cold climates and at high altitudes in Mongolia and in northern China. The nucleotide sequence of pika UCP1 was highly homologous to UCP1 of other species, and the deduced amino acid sequence had some common domains for UCP, including six mitochondrial carrier protein motifs and a putative purine-nucleotide binding site. RT-PCR and Western blot analyses revealed that both UCP1 mRNA and protein were expressed exclusively in the interscapular adipose tissue. These results suggest that pika UCP1 contributes to heat production in brown adipose tissue, as do those in other species.
- 公益社団法人 日本獣医学会の論文
著者
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OKAMATSU-OGURA Yuko
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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Omachi Asako
Department Of Health And Nutrition Faculty Of Human Science Hokkaido Bunkyo University
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Kimura Kazuhiro
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Matsumoto Takaaki
Laboratory For Exercise Physiology And Biomechanics Chukyo University
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SAITO Masayuki
Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University
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KITAO Naoya
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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YAHATA Takahiro
Department of Nutritional Sciences, Faculty of Health and Welfare Science, Nayoro City University
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OMACHI Asako
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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