Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein
スポンサーリンク
概要
- 論文の詳細を見る
Clonidine, an α_2-agonist, has been shown to be useful in the treatment of hepatic portal hypertension in cirrhosis. The mechanism has been attributed to a clonidine-induced decrease in sympathetic activity. While clonidine has been shown to stimulate the α_2-adrenoceptors of blood vessels, there is limited knowledge of the effects of clonidine on the circular muscle of the hepatic portal vein which regulates its blood flow. To investigate clonidine-induced contraction of the circular muscle of the hepatic portal vein and to clarify the possible role of the endothelium in the contraction, we examined the effects of clonidine on the isometric contraction of endothelium-intact and -removed ring preparations of the rat hepatic portal vein. In endothelium-intact preparations, clonidine caused a concentration-dependent increase in the amplitude of contractions. Inhibition of NO synthesis with N^ω-nitro-L-arginine (L-NNA) elevated the resting tone, and increased the amplitude of the clonidine-induced contractions. Inhibition of cyclooxygenase by diclofenac did not change the amplitude of the clonidine-induced contractions observed both in the presence and absence of L-NNA. Application of a single concentration of clonidine induced a clear increase in amplitude of both twitch and tonic contractions. Twitch and tonic contractions induced by clonidine were inhibited by yohimbine. When the endothelium was damaged by sodium deoxycholate, tonic contractions induced by clonidine were completely suppressed, whereas the increase in twitch contractions was not influenced by chemical damage of the endothelium. Neither SKF-96365, a nonselective cation channel blocker, nor superoxide dismutase, a free radical scavenger, in the presence of catalase, changed the tonic contraction induced by clonidine. These results indicate that stimulation of α_2-adrenoceptors enhanced twitch contractions and induced tonic contractions in the circular muscle of the rat hepatic portal vein, especially in the absence of NO. The latter, but not the former, occurs through an endothelium-dependent pathway.
- 日本平滑筋学会の論文
著者
-
Kimura Shinichi
Department Of Physics And Graduate School Of Science And Technology Kobe University
-
KITAMURA KENJI
Department of Pediatrics, Mie Hospital National Sanatorium
-
Kitamura Kenji
Department Of Pediatrics Mie National Hospital
-
Shimamura K
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
-
KIMURA Shinichi
National Institute of Information and Communications Technology
-
SHIMAMURA Keiichi
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
-
OHASHI Atsuko
Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences Universit
-
Ohashi Atsuko
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
-
Ohashi Atsuko
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science
-
Shimamura Keiichi
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
-
Kimura Shinichi
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
-
Kimura S
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
-
Kawata K
Department Of Physiological Sciences And Molecular Biology Fukuoka Dental College
-
Kimura Shinichi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
-
TOBA Miyuki
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
-
Toba Miyuki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of
-
Kitamura Kenji
Department Of Chemical Engineering Faculty Of Engineering Kyoto University
関連論文
- Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.2
- Indirect and Direct Energy Gaps in Kondo Semiconductor YbB_(Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Carrier-induced Magnetic Circular Dichloism in the Magnetoresistive Pyrochlore Tl_2Mn_2O_7(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Optical Spectra of the Kondo Semiconductor YbB_
- PHARMACOKINETICS AND CLINICAL EFFECTS OF CEFOZOPRAN IN PEDIATRIC PATIENTS
- Photoemission, Inverse Photoemission and Optical Studies of Rare-Earth Hexaborides
- On-orbit servicing and its breakthrough approach using small satellite : Rendezvous and fly-around technology for uncooperative target(WSANE2006)
- BS-6-12 Development of Equipments for Rendezvous Fly-around Experiments on SmartSat-1(BS-6.Observation, communication and positioning technology of equipments mounted on satellite, aircraft, ship and ground,ENGLISH SESSION)
- SmartSat-1 : On Orbit Experiment Plan Using Mini-Satellite(Small satellite (2), Workshop for Space, Aeronautical and Navigational Electronics (W S A N E 2005))
- SmartSat-1 : On Orbit Experiment Plan Using Mini-Satellite
- Effects of Flufenamic Acid on Smooth Muscle of the Carotid Artery Isolated from Spontaneously Hypertensive Rats
- Ca^-Sensitivity of Portal Vein Circular Muscle from Normotensive and Hypertensive Rats
- On-Orbit Experiment of Vision-Based Motion Estimation and Tracking of Tumbling Object in Space
- Moon Tracking Attitude Control Experiment of a Bias Momentum Micro Satellite "μ-LabSat"
- Results of the MicroLabSat project(Small satellite (2), Workshop for Space, Aeronautical and Navigational Electronics (W S A N E 2005))
- Results of the MicroLabSat project
- Moon Tracking Attitude Control Experiment of a Bias Momentum Micro Satellite “μ-LabSat”
- SB-8-5 In-orbit Demonstration of Orbital Maintenance System Using COTS Technologies(Small Satellite 1)(SB-8. Results of Various Satellite Missions)
- VISUAL FEEDBACK ATTITUDE CONTROL EXPERIMENT OF A BIAS MOMENTUM MICRO SATELLITE
- Preliminary experiments on technologies for satellite orbital maintenance using Micro-LabSat 1
- L-Arginine-induced current in portal venous smooth muscle cells
- THE EFFECT OF PERICARDIUM ON CARDIAC FUNCTION IN EXPERIMENTAL HEART FAILURE : VOLUME LOADING AND UNLOADING : Heart Failure : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Involvement of P/Q-type Voltage-dependent Calcium Channels in the Streptozotocin-induced Hyperalgesia in Mice
- Conjugated Linoleic Acid Deteriorates Insulin Resistance in Obese/Diabetic Mice in Association with Decreased Production of Adiponectin and Leptin
- SB-8-4 Result of Advanced Missions of MicroLabSat(Small Satellite 1)(SB-8. Results of Various Satellite Missions)
- Endothelium-Dependent Relaxation in Pulmonary Arteries of L-NAME-Treated Wistar and Stroke-Prone Spontaneously Hypertensive Rats
- Effect of Chronic Treatment with Perindopril on Endothelium-dependent Relaxation of Aorta and Carotid Artery in SHRSP
- Involvement of Endothelium-Derived Factors in Controlling the Active Tone of Smooth Muscle in Aorta from Hypertensive Rats
- Influences of Endothelium on the Time Course of Noradrenaline-, 5-HT-, Prostaglandin F_- and High-K^+- Induced Contractions in Aortae of WKY and SHRSP
- Effects of Chronic Treatment with Carvedilol on Smooth Muscle Tone and Endothelium-Dependent Relaxation of Aorta in Stroke-Prone Spontaneously Hypertensive Rats
- Clinical features of measles in immunocompromised children
- State-Dependent Inhibition of L-type Ca^ Channels in A7r5 Cells by Cilnidipine and Its Derivatives
- Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein
- Evidence for the involvement of the cyclooxygenase-metabolic pathway in diclofenac-induced inhibition of spontaneous contraction of rat portal vein smooth muscle cells
- Hypertension and Impairment of Endothelium-Dependent Relaxation of Arteries from Spontaneously Hypertensive and L-NAME-Treated Wistar Rats
- Difference in Effects of Stretch on Depressive Effect of Endothelium-Derived Nitric Oxide on Noradrenaline- and High-K^+-Induced Contractions between the Aortae from Normotensive and Spontaneously Hypertensive Rats
- Transmural Field Stimulation-induced Relaxation in the Rat Common Hepatic Artery
- Altered β-Adrenoceptor-Mediated Responses in the Gastric Smooth Muscle of Hypertensive Rats
- Laser beam propagation in ground-to-OICETS laser communication links
- Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca^ Channels Ca_v3.1 and Ca_v3.2
- P-4(第25回福岡歯科大学学会総会抄録)
- Mechanisms Mediating the Vasorelaxing Action of Eugenol, a Pungent Oil, on Rabbit Arterial Tissue
- EFFECT OF GUANETHIDINE, CLONIDINE AND GUANFACINE ON URINARY CATECHOLAMINE EXCRETION IN COLD-STRESSED SPONTANEOUSLY HYPERTENSIVE RATS
- Role of Endothelium and Adventitia on Eugenol-Induced Relaxation of Rabbit Ear Artery Precontracted by Histamine
- Simultaneous Activation of Ca^-Dependent K^+ and Cl^- Currents by Various Forms of Stimulation in the Membrane of Smooth Muscle Cells from the Rabbit Basilar Artery
- A FAULT-TOLERANT CONTROL ALGORITHM OF REDUNDANT SPACE MANIPULATOR FOR REMOTE INSPECTION
- Serotonin_ Receptor-Mediated Synaptic Response in the Rat Medial Prefrontal Cortex Is Altered by Early Life Stress : In Vivo and In Vitro Electrophysiological Studies
- Fluorine-Doped Tin Dioxide Thin Films Prepared by Thermal Decomposition of Metallic Complex Salts
- Chloride Channels and Their Functional Roles in Smooth Muscle Tone in the Vasculature
- A Case of the Kugelberg-Welander Syndrome Complicated with Cardiac Lesions
- Early Life Stress Affects the Serotonergic System Underlying Emotional Regulation
- Vitamin B12 treatment for rhythm disorders in SHRSP
- Actions of nipradilol (K-351), a new .ALPHA.- and .BETA.-adrenoceptor blocker, on the rabbit portal vein.
- Suppression of lysophosphatidylcholine-induced abnormal automaticity by verapamil in canine Purkinje fibers.