Effects of Flufenamic Acid on Smooth Muscle of the Carotid Artery Isolated from Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Endothelium-removed carotid artery strips from stroke-prone spontaneously hypertensive rats spontaneously developed a tonic myogenic contraction. Flufenamic acid reduced the resting tone observed during superfusion with Tyrode's solution, in a concentration-dependent manner. Flufenamic acid also inhibited contractions produced by high-K^+ solutions in a concentration-dependent manner. The resting membrane potential of smooth muscle cells in the artery was around -32 mV, with occasional oscillatory potentials. Flufenamic acid hyperpolarized the membrane in a concentrationdependent manner. The voltage-dependent outward currents recorded in isolated cells with micropipettes filled with high-K^+ solution (holding potential, -60 mV) were enhanced by flufenamic acid and inhibited by tetraethylammonium. When the recording micropipette was filled with high Cs^+ to inhibit the K^+-current, depolarizing step pulses evoked nifedipine-sensitive inward currents. Flufenamic acid inhibited the inward currents. These results indicate that flufenamic acid inhibits the spontaneous active tone of the carotid artery by inhibiting L-type Ca^<2+>-channels and possibly by membrane hyperpolarization through activation of the voltage-dependent K^+-channels.
- 日本平滑筋学会の論文
著者
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Kimura Shinichi
Department Of Physics And Graduate School Of Science And Technology Kobe University
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KITAMURA KENJI
Department of Pediatrics, Mie Hospital National Sanatorium
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Ito Yasuko
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Kitamura Kenji
Department Of Pediatrics Mie National Hospital
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Shimamura K
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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KIMURA Shinichi
National Institute of Information and Communications Technology
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Zou Li-bo
Faculty Of Pharmaceutical Sciences Kinki University
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SHIMAMURA Keiichi
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
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ZHOU Ming
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
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Zou L.-B.
Faculty of Pharmaceutical Sciences, Kinki University
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SEKIGUCHI Fumiko
Faculty of Pharmaceutical Sciences, Kinki University
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SUNANO Satoru
Faculty of Pharmaceutical Sciences, Kinki University
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Shimamura Keiichi
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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Kimura Shinichi
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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Zhou Ming
Department Of Anatomy Akita University School Of Medicine
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Zhou Ming
Department Of Pharmacology Medical College Of Qingdao University
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Sunano S
Kinki Univ. Osaka Jpn
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Sunano Satoru
Faculty Of Pharmaceutical Science Kinki University
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Kimura S
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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Kawata K
Department Of Physiological Sciences And Molecular Biology Fukuoka Dental College
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Kimura Shinichi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Sekiguchi F
Kinki Univ. Osaka Jpn
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Sekiguchi Fumiko
Faculty Of Pharmaceutical Science Kinki University
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Ito Yasuko
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of
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Zhou Ming
Department Of Anatomy Akita University Graduate School Of Medicine And Faculty Of Medicine
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Kitamura Kenji
Department Of Chemical Engineering Faculty Of Engineering Kyoto University
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