Transmural Field Stimulation-induced Relaxation in the Rat Common Hepatic Artery
スポンサーリンク
概要
- 論文の詳細を見る
Hepatic arteries are reportedly innervated by vasoconstrictor and vasodilator nerves. Experiments were carried out to investigate the possible involvement of calcitonin gene related peptide(CGRP)and nitric oxide as neurotransmitters during the relaxation of the rat common hepatic artery produced by transmural electrical field stimulation(ES). Common hepatic arteries were excised under ether-anesthesia from 6 weeks-old female rats, and isometric tensions recorded from endothelium-damaged ring preparations. In the presence of atropine and guanethidine, ES relaxed arteries which had been previously contracted with vasopressin. The relaxation response to ES was attenuated by either tetrodotoxin or capsaicin-pretreatment. CGRP induced a concentration-dependent relaxation, which was inhibited by the CGRP antagonist CGRP_<8-37>. The ES-induced relaxation was attenuated either slightly by the nitric oxide synthesis inhibitor L-nitroarginine(L-NNA)or markedly by CGRP_<8-37>. The relaxation response was nearly abolished in the presence of both CGRP_<8-37> and L-NNA. These results may indicate that the nerve stimulation-induced vasodilatation of the rat common hepatic artery is mediated mainly by CGRP and partly by nitric oxide.
- 日本平滑筋学会の論文
著者
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Kimura Shinichi
Department Of Physics And Graduate School Of Science And Technology Kobe University
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Shimamura K
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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KIMURA Shinichi
National Institute of Information and Communications Technology
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SHIMAMURA Keiichi
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
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Saito Hideya
Department Of Cardiovascular Medicine And Pharmacology. Hokkaido University
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Saito Hideya
Department Of Basic Sciences Japanese Red Cross Hokkaido College Of Nursing
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Shimamura Keiichi
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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Kimura Shinichi
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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Yamamoto Kazuo
The Life Science Institute Kinki University
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Sunano S
Kinki Univ. Osaka Jpn
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Sunano Satoru
School Of Pharmaceutical Sciences Kinki University
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Kimura S
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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Kimura Shinichi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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SEKIGUCHI Fumiko
School of Pharmaceutical Sciences, Kinki University
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Sekiguchi F
Kinki Univ. Osaka Jpn
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Sekiguchi Fumiko
School Of Pharmaceutical Sciences Kinki University
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