Unaltered Caffeine-induced Relaxation in the Aorta of Stroke-Prone Spontaneously Hypertensive Rats(SHRSP)
スポンサーリンク
概要
- 論文の詳細を見る
Caffeine-induced relaxation was studied in aortic segments from Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Although acetylcholine-induced endothelium-dependent relaxation was impaired in preparations from SHRSP, the relaxation induced by caffeine was identical in both groups. In addition, caffeine-induced relaxation was not affected by removal of the endothelium in either group. The relaxation induced by N^6,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate (db-cAMP), a membrane-permeable analog of adenosine 3':5'-cyclic monophosphate (cAMP), was identical in both groups. No significant difference was observed in the increase in cAMP content induced by caffeine in the aortic smooth muscle between the groups, although the basal content was significantly higher in preparations from SHRSP. These results suggest that the relaxation induced by caffeine in these preparations is brought about by its direct effect on smooth muscle and that the response of the smooth muscle to caffeine, including cAMP production, is not altered in preparations from SHRSP compared with those from WKY.
- 日本平滑筋学会の論文
著者
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Miyake Yoshimasa
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Sunano S
Kinki Univ. Osaka Jpn
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Sunano Satoru
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Sekiguchi F
Kinki Univ. Osaka Jpn
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Sekiguchi Fumiko
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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KASHIMOTO Takafumi
Department of Anatomy and Physiology, School of Pharmaceutical Sciences, Kinki University
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Kashimoto Takafumi
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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