Effects of Chronic Treatment with Carvedilol on Smooth Muscle Tone and Endothelium-Dependent Relaxation of Aorta in Stroke-Prone Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of chronic treatment of stroke-prone spontaneously hypertensive rats (SHRSP) with carvedilol, an agent which has both α- and β-adrenoceptor blocking actions, on spontaneous muscle tone and on structural and functional abnormalities of endothelium were studied. The treatment of SHRSP with the drug of the dose of 30 to 200 mg/kg/day lowered the blood pressure significantly. Spontaneous muscle tone in endothelium-removed preparation disappeared by the treatment. Noradrenaline-induced contraction was depressed by the treatment in endothelium-intact preparation but not in endothelium-removed preparation. The treatment prevented the structural and functional abnormalities of endothelium. Similar results were obtained by the treatment with propranolol. These results indicate that carvedilol prevented abnormal contraction of SHRSP aorta through protective effects on smooth muscle and endothelium. These effects may play roles in blood pressure lowering effect of carvedilol.
- 日本平滑筋学会の論文
著者
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KIMURA Shinichi
National Institute of Information and Communications Technology
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Matsuda K
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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SEKIGUCHI Fumiko
Faculty of Pharmaceutical Sciences, Kinki University
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SUNANO Satoru
Faculty of Pharmaceutical Sciences, Kinki University
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MATSUDA Kyoko
Faculty of Pharmaceutical Sciences, Kinki University
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NAKAMURA Akiko
Faculty of Pharmaceutical Sciences, Doshisha Women's University
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Yamamoto Kazuo
The Life Science Institute Kinki University
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Nakamura Akiko
Faculty Of Pharmaceutical Sciences Doshisha Women's University
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Sunano S
Kinki Univ. Osaka Jpn
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Sunano Satoru
Faculty Of Pharmaceutical Science Kinki University
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Hashimoto Hiroo
Tokyo R & D Center Daiichi Rharmaceutical Co. Ltd.
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Kimura S
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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TANAKA Makoto
Tokyo R & D Center, Daiichi Pharmaceutical Co., Ltd.
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YAMAMOTO Kazuo
Faculty of Pharmaceutical Sciences and Research Institute of Hypertension, Kinki University
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SHIBUTANI Tomoko
Tokyo R & D Center, Daiichi Rharmaceutical Co., Ltd.
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SHIMAMURA Keiichi
Faculty of Pharmaceutical Sciences and Research Institute of Hypertension, Kinki University
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Sekiguchi F
Kinki Univ. Osaka Jpn
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Sekiguchi Fumiko
Faculty Of Pharmaceutical Science Kinki University
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Shibutani Tomoko
Tokyo R & D Center Daiichi Pharmaceutical Co. Ltd.
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Nakamura Akiko
Faculty Of Pharmaceutical Sciences And Research Institute Of Hypertension Kinki University
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Tanaka M
Denso Corp. Nisshin‐shi Jpn
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Hashimoto Hiroo
Tokyo R & D Center, Daiichi Parmaceutical Co., Ltd.
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