Hypertension and Impairment of Endothelium-Dependent Relaxation of Arteries from Spontaneously Hypertensive and L-NAME-Treated Wistar Rats
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概要
- 論文の詳細を見る
Effects of chronic treatment of normotensive Wistar rats with N^ω-nitro-L-arginine methyl ester(L-NAME)on blood pressure and on endothelium-dependent relaxation of the aorta, carotid and iliac arteries were studied. The endothelium-dependent relaxation was compared in arteries from normotensive Wistar Kyoto rats(WKY)and genetically hypertensive rats(stroke-prone spontaneously hypertensive rats, SHRSP). Chronic treatment of normotensive Wistar rats with L-NAME caused an elevation of blood pressure. The elevated blood pressure at 15 weeks of age was significantly higher in these animals than that of untreated Wistar rats, but lower than that of SHRSP. Endothelium-dependent relaxation of the arteries induced by acetylcholine(ACh)was almost abolished by chronic treatment with L-NAME. The remaining small relaxation in arteries from L-NAME-treated rats was completely inhibited by application of L-NAME(10^<-4>M). In such preparations, higher concentrations of ACh induced a contraction, which was abolished by removal of the endothelium or by an application of indomethacin(10^<-5>M). Endothelium-independent relaxation induced by sodium nitroprusside was similar between preparations from untreated and L-NAME-treated Wistar rats. Endothelium-dependent relaxation was significantly impaired in preparations from SHRSP, when compared with that in those from WKY. However, the impairment was less prominent in preparations from SHRSP than in those from L-NAME-treated rats. These results suggest that the impairment of endothelium-dependent relaxation in the arteries from L-NAME-treated rats is not due to the elevated blood pressure resulting from the chronic treatment, and that impairment of NO sunthesis by endothelium does not play a major role in the initiation of hypertension in SHRSP.
- 日本平滑筋学会の論文
著者
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Miyake Yoshimasa
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Shimamura K
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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KIMURA Shinichi
National Institute of Information and Communications Technology
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SHIMAMURA Keiichi
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University
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Shimamura Keiichi
Department Of Pharmacological Sciences School Of Pharmaceutical Sciences Health Sciences University
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Kimura Shinichi
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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Yamamoto Kazuo
The Life Science Institute Kinki University
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Sunano S
Kinki Univ. Osaka Jpn
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Sunano Satoru
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Kimura S
Space-info Network Group New Generation Wireless Center National Institute Of Information And Commun
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SEKIGUCHI Fumiko
Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki University
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HIRAKAWA Atsuko
Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki University
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NAKAHIRA Tomohiro
Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki University
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YAMAOKA Miku
Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki University
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Sekiguchi F
Kinki Univ. Osaka Jpn
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Sekiguchi Fumiko
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Yamaoka Miku
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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Nakahira Tomohiro
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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Hirakawa Atsuko
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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