Contraction of Arterial Smooth Muscle of Normotensive and Spontaneously Hypertensive Rats by Manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (MnTMPyP)
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概要
- 論文の詳細を見る
Manganese(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), which has been known as a cell permeable superoxide dismutase mimetic, induced concentration-dependent contraction in rat carotid artery acting directly on smooth muscle. The contractile action was more prominent in the preparation from stroke-prone spontaneously hypertensive rats (SHRSP) compared with that from Wistar Kyoto rats (WKY). It was abolished by the removal of extracellular Ca2+ or the application of verapamil. These results suggest that the MnTMPyP-induced contraction is brought about by Ca2+ influx through voltage-dependent Ca2+ channels (VDCC) and that the difference in VDCC is the cause of the difference in MnTMPyP action between preparations from WKY and SHRSP.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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Sunano Satoru
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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Sekiguchi Fumiko
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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SEO Mikako
Department of Anatomy and Physiology, School of Pharmaceutical Sciences, Kinki University
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Seo Mikako
Department Of Anatomy And Physiology School Of Pharmaceutical Sciences Kinki University
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