Early Life Stress Affects the Serotonergic System Underlying Emotional Regulation
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概要
- 論文の詳細を見る
Traumatic events in early life are implicated in an increased risk of psychiatric diseases, such as depression and anxiety disorders. Serotonin is thought to play a central role in stress-induced psychiatric diseases. Serotonergic systems, including neural organization and receptor function, could dramatically change with each developmental stage. Here, we reviewed the persistent influence of early life stress on emotional regulation, focusing on the serotonergic system in rats. An aversive stimulus, foot shock (FS), during the early postnatal period (2–3 weeks after birth) produced behavioral, neuroanatomical and electrophysiological changes accompanied by serotonergic dysfunction, especially functional impairment of the serotonin (5-hydroxytryptamine; 5-HT)1A receptor in the cortico-limbic area. These findings suggest that normalization of the cortico-limbic serotonergic function has therapeutic potential for early stress-induced emotional disturbance.
著者
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Togashi Hiroko
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Kimura Shinichi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Shikanai Hiroki
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
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Togashi Hiroko
Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Kimura Shinichi
Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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