Synaptic Modulation via Basolateral Amygdala on the Rat Hippocampus Medial–Prefrontal Cortex Pathway in Fear Extinction
スポンサーリンク
概要
- 論文の詳細を見る
The present study elucidated the functional role of modulatory effects of basolateral amygdala (BLA) on synaptic transmission in the rat hippocampus medial–prefrontal cortex (mPFC) pathway, compared with the hippocampal dentate gyrus (DG). Exposure to conditioned fear stress (CFS) or prior BLA activation enhanced tetanus-induced long-term potentiation (LTP) in DG. A similar synaptic response was found by low frequency stimulation (LFS) prior to tetanus. In mPFC, they did not affect LTP, but prior BLA activation, as well as pretreatment with the N-methyl-<span style="font-variant: small-caps;">d</span>-aspartate (NMDA)-receptor antagonist MK-801 (0.1 mg/kg, i.p.), suppressed LFS-primed LTP. This BLA-mediated synaptic pattern was mimicked by synaptic changes observed in the fear extinction process; prior BLA activation suppressed the synaptic potentiation responsible for extinction retrieval and attenuated decreases in fear-related freezing behavior. These data suggest that LFS-primed LTP in mPFC is related to the neural basis of extinction. Extinction-related synaptic potentiation did not occur in a juvenile stress model that exhibited extinction deficit. In addition, LFS-primed LTP was suppressed in this model, which was reversed by the NMDA-receptor agonist <span style="font-variant: small-caps;">d</span>-cycloserine (15 mg/kg, i.p.). These findings suggest that modulatory effects of BLA on synaptic function in the hippocampus–mPFC pathway play a significant role in fear extinction in rats.
- 公益社団法人 日本薬理学会の論文
著者
-
Saito Yasuhiro
Department Of Applied Physics Osaka University
-
Togashi Hiroko
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
-
MATSUMOTO Machiko
Department of Pharmacology, Hokkaido University Graduate School of Medicine
-
HIRAIDE Sachiko
Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
-
Inoue Sumitaka
Department Of Pharmacology School Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Yanagawa Yoshiki
Department Of Pharmacology School Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Togashi Hiroko
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
-
Kamiyama Hidekazu
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
-
Shimamura Kei-ichi
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
-
Hiraide Sachiko
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
-
Yanagawa Yoshiki
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
-
Inoue Sumitaka
Department of Pharmacology, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Japan
関連論文
- Pleomorphic ventricular tachycardia originating from Purkinje fiber network of left anterior fascicle
- Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice
- Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells
- Which is most Beneficial for Preserving Cardiac Function and Coronary Microvasculaturein DCM, ACE-I, ARB or Two in Combination? (Cardiac Hypertrophy/Cardiomyopathy 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-084 Surgical Ventricular Reconstruction Improves Myocardial Oxidative Efficiency Assessed by ^ C-acetate PET and Echocardiography in Patients with Severe Heart Failure(OE15,Cardiac Function (Clinical) (M),Oral Presentation (English),The 73rd Annual
- PJ-573 Chronic Treatment with Endothelin Receptor Antagonist Normalizes the Altered Cerebral Capillary Density in the Frontal Cortex of SHR-SP Rats(Cerebrovascular circulation/Stroke-3, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- PJ-320 Endothelin Antagonism Greatly Reverses Upregulated Renin-Angiotensin System in the Hypertrophied Heart of SHR-SP(Cardiac hypertrophy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-188 Dual Endothelin Receptor Antagonist Reverses the Upregulated VEGF-KDR Axis in Frontal Cortex of SHR-SP without Modulating the Cerebral Blood Flow(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual S
- Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure
- Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats
- OJ-152 Do JCD, IDF and NCEP Criteria of Metabolic Syndrome Predict Cardiovascular Events? : 3-Year Cohort Study of 3,343 Japanese Men(Preventive medicine / Epidemiology / Education(02)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of
- Lower High-Density Lipoprotein Cholesterol is a Significant and Independent Risk for Coronary Artery Disease in Japanese Men
- PJ-195 Decreased Glomerular Filtration Rate is a Significant and Independent Risk for In-Hospital Mortality in Japanese Patients with Acute Myocardial Infarction(PJ033,Preventive Medicine/Epidemiology/Education 1 (H),Poster Session (Japanese),The 73rd Ann
- Liposome-Encapsulated Hemoglobin Ameliorates Impairment of Fear Memory and Hippocampal Dysfunction After Cerebral Ischemia in Rats
- Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal – Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats
- PJ-098 Effects of Smoking Cessation on Coronary Endothelial Dysfunction in Young and Middle-aged Healthy Smokers(PJ017,Nuclear Cardiology (PET) (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-ll Acetate PET
- Plasma Interleukin-6 and Tumor Necrosis Factor-α Can Predict Coronary Endothelial Dysfunction in Hypertensive Patients
- Quantitative Assessment of Regional Myocardial Blood Flow and Myocardial Flow Reserve Using Tc-99m-sestamibi Imaging(Nuclear Cardiology 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Assessment of Myocardial Beta-adrenergic Receptor Density in Patients with Congestive Heart Failure : PET Study with C-11-labeled-CGP-12177(Nuclear Cardiology 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Evaluation of Effects of Polymorphism for Metabolic Enzymes on Pharmacokinetics of Carvedilol by Population Pharmacokinetic Analysis(Biopharmacy)
- Hypofibrinolysis Downregulates Coronary Capillary Network Remodeling in Aged Obese Diabetic Rats : Implications for Increased Myocardial Vulnerability to Ischemia in Diabetes
- Effects of hemoglobin derivatives on the liver microcirculation system ; evaluation of the s-nitroso-polyethylene glycol modified hemoglobin as an artificial oxygen carrier
- Coronary Capillary Remodeling in Non-Insulin-Dependent Diabetic Rats: Amelioration by Inhibition of Angiotensin Converting Enzyme and Its Potential Clinical Implications
- The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells
- An S-Nitrosylated Hemoglobin Derivative Protects the Rat Hippocampus From Ischemia-Induced Long-Term Potentiation Impairment With a Time Window
- OE-148 Atorvastatin Increases Cholesterol Absorption and Serum CXCL16 Levels in Patients with Acute Coroary Syndrome Compared with Pravastatin(OE25,ACS/AMI (Clinical/Treatment) 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- An s-Nitrosylated Hemoglobin Derivative Protects Rat Brain from Cerebral Ischemia
- VEGF, Its Receptors and Other Angiogenic Growth Factors Are Altered Potentially in an Age-Related Manner in SHRSP Heart
- Equilibrium of dissolving species in aqueous H_2SiF_6 solution during the liquid phase deposition reaction(Aqueous Solution Science for Ceramic Processing II)
- PE-471 The Effect of Pravastatin on ROCK1 in Angiotensin II-Induced Cardiac Fibrosis(Chronic coronary heart disease/Remodeling-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-010 Influence of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Pravastatin, on Angiotensin II-Induced Left Ventricular Remodeling(Chronic coronary heart disease/Remodeling-1 (IHD) OE2,Oral Presentation (English),The 70th Anniversary Annu
- Platelet Aggregability in Patients with Hypertension Treated with Angiotensin II Type 1 Receptor Blockers
- Macrophage Specific Overexpression of Allograft Inflammatory Factor-1 Reduces Atherosclerosis in Vivo (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Brain perfusion SPECT in neuro-Behcet's disease: Discordance between Tc-99m-HMPAO and Tc-99m-ECD
- PE-025 Daidzein, Soy Phytoestrogen, Selectively Ameliorates Obesity-Related Hypertension in Mice and Humans(PE005,Metabolic Syndrome 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 6 Clinical Significance of Myocardial Blood Volume Measured by Contrast Echocardiography in Patients with Cardiac Hypertrophy and Failure(Frontiers in Diagnostic Echocardiography,Symposium 14 (SY-14) (M),The 73rd Annual Scientific Meeting of The Japanese
- Unstable Cavitation Behavior in a Circular-Cylindrical Orifice Flow
- Hole Dynamics in the Orthogonal-Dimer Spin System (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Hole-Doping Effects on a Two-Dimensional Kondo Insulator (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Hole-Doping Effects on a Two-Dimensional Kondo Insulator
- "P-61 Effect of 5-hydroxytryptamine (5-HT)_4 receptor modulation on abdominal afferent vagal nerve activity in ferrets and rats.
- PE-214 Pravastatin and Atorvastatin Were Equivalent in Reducing Inflammatory Markers in Acute Coronary Syndrome Despite Differences in Lowering LDL : PROVE-J Study(Infection/Inflammation/Immunity(02)(H),Poster Session(English),The 72nd Annual Scientific M
- Infective Endocarditis and Acute Purulent Pericarditis in a Patient with Hyperglycemia
- POTENTIATION OF TOXICITY AND POSITIVE INOTROPIC EFFECT OF OUABAIN BY FUROSEMIDE IN GUINEA PIG HEART
- Decreased Left Atrial Appendage Flow Velocity With Atrial Fibrillation Caused by Negative Inotropic Agents
- Does Coronary Flow Velocity Reserve Reflect the Residual Viability in Patients With Old Myocardial Infarction? : Transthoracic Doppler Echocardiographic study
- Changes in Synaptic Properties in Cortical-Limbic Communications Induced by Repeated Treatments With Fluvoxamine in Rats
- Detailed Morphology of Rubbed Alignment Layers and Surface Anchoring of Liquid Crystals
- Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
- Effects of Acute Repetitive Transcranial Magnetic Stimulation on Extracellular Serotonin Concentration in the Rat Prefrontal Cortex
- Pulse Dispersion due to Atrial Fibrillation Causes Arterial Thrombosis in a Rabbit Experimental Model
- Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan : A Report Frown the Japanese Cardiac Registry of Hears Failure in Cardiology (JCARE-CARD)
- Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats
- Functional Interaction between Serotonin and Other Neuronal Systems: Focus on In Vivo Microdialysis Studies
- EFFECT OF GUANETHIDINE, CLONIDINE AND GUANFACINE ON URINARY CATECHOLAMINE EXCRETION IN COLD-STRESSED SPONTANEOUSLY HYPERTENSIVE RATS
- Performance Assessment of Phased-Array Coil in Breast MR Imaging
- Serotonin_ Receptor-Mediated Synaptic Response in the Rat Medial Prefrontal Cortex Is Altered by Early Life Stress : In Vivo and In Vitro Electrophysiological Studies
- Novel Strain Rate Index of Contractility Loss Caused by Mechanical Dyssynchrony : A Predictor of Response to Cardiac Resynchronization Therapy
- Liquid Atomization Using a Rotary Bell Cup Atomizer : (Influence of Flow Characteristics of Liquid on Breakup Pattern)
- Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects
- Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Liposome-Encapsulated Hemoglobin Ameliorates Impairment of Fear Memory and Hippocampal Dysfunction After Cerebral Ischemia in Rats
- Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolvtic-like Effect in Rats
- Type II NKT Cells Stimulate Diet-Induced Obesity by Mediating Adipose Tissue Inflammation, Steatohepatitis and Insulin Resistance
- Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging With Generator-Produced Rubidium-82 PET
- Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation
- Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction : report from the Hokkaido acute myocardial infarction registry
- Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction
- Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats
- Mode of Death in Patients With Heart Failure and Reduced vs. Preserved Ejection Fraction : Report From the Registry of Hospitalized Heart Failure Patients
- Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival
- Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats
- Determination of Size of Representative Volume Element for Coke Using Homogenization Method Based on Digital Image of Actual Microstructure
- Quantification of the Existence Ratio of Non-Adhesion Grain Boundaries and Factors Governing the Strength of Coke Containing Low-Quality Coal
- Early Life Stress Affects the Serotonergic System Underlying Emotional Regulation
- Determination of Size of Representative Volume Element for Coke Using Homogenization Method Based on Digital Image of Actual Microstructure
- Relationship between Stroke-related Behavior and Plasma Norepinephrine Concentration in Stroke-prone Spontaneously Hypertensive Rats
- Chronobiological Study of Stroke-related Behavioral Changes in Stroke Prone Spontaneously Hypertensive Rats
- Synaptic Modulation via Basolateral Amygdala on the Rat Hippocampus Medial–Prefrontal Cortex Pathway in Fear Extinction
- Quantitative Evaluation for Relationship between Development of Pore Structure and Swelling of Coal in Carbonization of Single Coal Particle
- Down-regulated expression of family with sequence similarity 3, member B (FAM3B), in oral squamous cell carcinoma