Functional Interaction between Serotonin and Other Neuronal Systems: Focus on In Vivo Microdialysis Studies

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概要

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• In this review, the functional interactions between serotonin (5-HT) and other neuronal systems are discussed with the focus on microdialysis studies in the mammalian brain (mainly rats). 5-HT release is negatively regulated not only by somatodendritic 5-HT<SUB>1A</SUB> and terminal 5-HT<SUB>1B</SUB> (5-HT<SUB>1D</SUB>) autoreceptors but also by α<SUB>2</SUB>-adrenergic and μ-opioid heteroreceptors that are located on serotonergic nerve terminals. 5-HT by itself is involved in the inhibitory effects of noradrenaline release and the facilitatory regulation of dopamine release via multiple 5-HT receptors. Acetylcholine release appears to be regulated by inhibitory 5-HT<SUB>1B</SUB> heteroreceptors located on cholinergic nerve terminals. Long-term treatment with 5HT-uptake inhibitors and noradrenaline-uptake inhibitor produces desensitization of 5-HT<SUB>1A</SUB> autoreceptors and α<SUB>2</SUB>-heteroreceptors, respectively, which may be related therapeutically to the delayed onset of the effects of antidepressants. Some microdialysis studies have predicted that the combination of a 5-HT-uptake inhibitor and 5-HT<SUB>1A</SUB>-autoreceptor antagonist might produce much greater availability of 5-HT in the synaptic cleft in terms of much faster induction of subsensitivity of 5-HT<SUB>1A</SUB> autoreceptors. Clinical trials based on this hypothesis have revealed that combination therapy with a 5-HT-uptake inhibitor and 5-HT<SUB>1A</SUB>-autoreceptor antagonist ameliorated the therapeutic efficacy in depressive patients. Taken together, neurochemical approaches using microdialysis can contribute not only to clarification of the physiological role of the serotonergic neuronal systems but also might be a powerful pharmacological approach for the development of therapeutic strategies.

• 社団法人 日本薬理学会の論文
• 1996-03-01

著者

• Matsumoto Misako

  北海道大学 医学研究科免疫学

• Matsumoto M

  Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Yoshioka Mitsuhiro

  Facul.of Pharm.sci. Higashi-nippon-gakuen Univ. 1st Dept.of Pharmacol

• Yoshioka Mitsuhiro

  Hokkaido University Graduate School of Medicine

• Togashi Hiroko

  First Department Of Pharmacology Hokkaido University School Of Medicine

• SAITO Hideya

  First Department of Pharmacology, Hokkaido University School of Medicine

• Saito Hideya

  Dept. Basic Sci. Jpn. Red Cross Hokkaido College Nursing:dept Pharmacol. Heallth Sci. Univ.

• Saito Hideya

  Department Of Cardiovascular Medicine And Pharmacology. Hokkaido University

• Satoh H

  Environmental Health Science Tohoku University Graduate School Of Medicine

• Saito Hideya

  Dept. Of Pharm. School Of Med. Hokkaido Univ.

• Saito Hideya

  First Department Of Pharmacology Hokkaido University School Of Medicine

• Yoshioka Mitsuhiro

  First Dept. of Pharmacol., Hokkaido Univ. Sch. of Med.

• MATSUMOTO Machiko

  First Department of Pharmacology, Hokkaido University School of Medicine

• Matsumoto Machiko

  First Department Of Pharmacology Hokkaido University School Of Medicine

• Togashi Hiroko

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Saito H

  Tohoku Univ. Sendai

• Minami Masaru

  Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine

• Minami Masaru

  Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido

• Makita Masaaki

  Dept. Of Cardiovascular Med Hokkaido Univ.

• Monma Y

  National Research Inst. Metals Tsukuba‐city Jpn

• Yoshioka Mitsuhiro

  First Department Of Pharmacology Hokkaido University School Of Medicine

• Satoh Hiroshi

  Environmental Health Science Tohoku University Graduate School Of Medicine

• Yoshioka Mitsuhiro

  First Deparment of Pharmacology, Hokkaido University School of Medicine

• Togashi Hiroko

  First Deparment of Pharmacology, Hokkaido University School of Medicine

• Saito Hideya

  First Deparment of Pharmacology, Hokkaido University School of Medicine

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