自然免疫にかかわるToll-like receptor群の非自己認識機構
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概要
- 論文の詳細を見る
Toll-like receptors (TLRs) are pattern-recognition receptors that play key roles in detecting microbes and initiating inflammatory responses. Ten members of the TLR family have been identified in humans.TLRs consist of an extracellular domain containing leucine-rich repeats and a C-terminal flanking region,and a cytoplasmic signaling domain,called the Toll/IL-1 receptor homology domain. Each TLR recognizes a distinct ligand (s) and induces different,sometimes overlapping,immune responses. Here,I show that TLR2 recognizes bacterial lipoproteins,while TLR3 recognizes virus-derived double-stranded RNA and triggers downstream signals leading to interferon production.
- 日本生物物理学会の論文
- 2002-11-25
著者
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Matsumoto Misako
北海道大学 医学研究科免疫学
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Matsumoto M
Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine
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松本 美佐子
大阪府立成人病センター研究所免疫学部門, CREST TST
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