The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
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概要
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RNA virus infection is recognized by the RIG-I-likereceptors RIG-I and MDA5, which induce antiviralresponses including the production of type I inter-ferons (IFNs) and proinflammatory cytokines. RIG-Iis regulated by Lys63-linked polyubiquitination, andthree E3 ubiquitin ligases, RNF125, TRIM25, andRiplet, are reported to target RIG-I for ubiquitination.To examine the importance of Riplet in vivo, wegenerated Riplet-deficient mice. Fibroblasts, macro-phages, and conventional dendritic cells from Riplet-deficient animals were defective for the production ofIFN and other cytokines in response to infection withseveral RNA viruses. However, Riplet was dispens-able for the production of IFN in response to B-DNAand DNA virus infection. Riplet deficiency abolishedRIG-I activation during RNA virus infection, and themutant mice were more susceptible to vesicularstomatitis virus infection than wild-type mice. Thesedata indicate that Riplet is essential for regulatingRIG-I-mediated innate immune response againstRNA virus infection in vivo.
- 2010-12-16
著者
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Matsumoto Misako
北海道大学 医学研究科免疫学
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Matsumoto M
Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine
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Seya Tsukasa
大阪府立成人病センター研究所 免疫学部門
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Seya Tsukasa
北海道大学 医学研究科免疫学
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Seya Tsukasa
Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases:probrain
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松本 美佐子
Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine
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Seto Toshiyuki
Daparment Of Virology
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Matsumoto Masanori
Laboratory Of Immunodynamics Department Of Microbiology And Immunology Osaka University Graduate Sch
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