Molecular Cloning of a Complementary DNA for a Membrane Cofactor Protein (MCP, CD46)/Measles Virus Receptor on Vero Cells and Its Functional Characterization

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概要

• 論文の詳細を見る

• We isolated a 1257-bp cDNA encoding a membrane cofactor protein (MCP, CD46)/measles virus (MV) receptor-like protein from a cDNA library of Vero cells, in which wild MV strains were established. Vero cells contain MCP mRNA splice products encoding different cytoplasmic tails like human cells. The deduced amino acid sequence of the cDNA was 86% identical to that of human MCP. Vero cell MCP expressed on CHO cells was recognized by monoclonal antibodies against human MCP, and served as a potent MV receptor. In addition, Vero MCP was as effective as human MCP in human factor I-mediated C3b cleavage. Thus, the high MV susceptibility of Vero cells can in part be attributed to an MCP-like molecule that is structurally and functionally similar to human MCP.

• 公益社団法人日本薬学会の論文
• 1996-12-15

著者

• SEYA TSUKASA

  Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine

• Seya Tsukasa

  大阪府立成人病センター研究所 免疫学部門

• Seya Tsukasa

  北海道大学 医学研究科免疫学

• Seya Tsukasa

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases:probrain

• Murakami Yukihisa

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Mukarami Yukihisa

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Murakami Yukihisa

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Murakami Yukihisa

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)

• Seya Tsukasa

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases

• KuRITA Mitsue

  Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases

• NAGASAWA Shigeharu

  Department of Pharmaceutical Sciences, Hokkaido University

• MURAKAMI Yusuke

  Faculty of Pharmaceutical Sciences, Hokkaido University

• NAGASAWA Shigeharu

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Murakami Y

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Kurita M

  Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University

• Nagasawa S

  Department Of Pharmaceutical Sciences Hokkaido University

• Nagasawa Shigeharu

  Faculty Of Pharmaceutical Sciences Hokkaido University

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