New Strategy for Indole Synthesis from Ethyl Pyrrole-2-carboxylate (Synthetic Studies on Indoles and Related Compounds. XXXIX)
スポンサーリンク
概要
- 論文の詳細を見る
As a synthetic application of the previously reported C_4-acylation of ethyl pyrrole-2-carboxylate (1), a new strategy for indole synthesis was developed. Ethyl pyrrole-2-carboxylate (1) was allowed to react with succinic anhydride or 3-methoxycarbonylpropionyl chloride to give, in good yield, a C_4-succinyl derivative of 1,which was converted into ethyl 7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate (6) as a key intermediate for indole synthesis. Starting from 6,several indoles functionalized on the benzene moiety were synthesized.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Ohtsuka Masanori
School Of Pharmaceutical Sciences Toho University
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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TANI Mayo
Faculty of Pharmaceutical Sciences,Tokushima Bunri University
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Tani M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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MURAKAMI Yasuoki
School of Pharmaceutical Sciences, Toho University
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YOKOYAMA Yuusaku
School of Pharmaceutical Sciences, Toho University
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TANI Masanobu
School of Pharmaceutical Sciences, Toho University
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ARIYASU Takahiro
School of Pharmaceutical Sciences, Toho University
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KOGA Terumi
School of Pharmaceutical Sciences, Toho University
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OGAWA Yumi
School of Pharmaceutical Sciences, Toho University
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Ogawa Yumi
School Of Pharmaceutical Sciences Toho University
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Koga Terumi
School Of Pharmaceutical Sciences Toho University
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Yokoyama Y
School Of Pharmaceutical Sciences Toho University
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Ariyasu Takahiro
School Of Pharmaceutical Sciences Toho University
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Murakami Yasuoki
School Of Pharmaceutical Sciences Toho University
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Yokoyama Yuusaku
School of Pharmaceutical Science, Toho University
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