Synthesis of VIP-Lipopeptide using a New Linker to Modify Liposomes: Towards the Development of a Drug Delivery System for Active Targeting
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概要
- 論文の詳細を見る
A new component for the solid phase peptide synthesis of lipopeptide, 2-[(4R,5R) -5-({[(9H-fluoren-9-yl)methoxy]-carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl) methoxy]acetic acid (2), was designed and synthesized from (-)-2,3-O-isopropylidene-d-threitol (3) in 4 steps. The key step was the selective alkylation of 3 with benzyl bromoacetate in the presence of Cs2CO3. Vasoactive intestinal peptide (VIP)-lipopeptide (1) incorporating this linker was synthesized by solid phase peptide synthesis.
著者
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Yano Kenji
School Of Engineering Hokkaido Tokai University
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Terada Katsuhide
School Of Pharmaceutical Sciences Toho Univ.
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SUZUKI Hideharu
School of Pharmaceutical Sciences, Toho University
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Suzuki Hideharu
School Of Pharmaceutical Sciences Toho University
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Yokoyama Yuusaku
School of Pharmaceutical Science, Toho University
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Hikawa Hidemasa
School of Pharmaceutical Science, Toho University
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Ichihara Risa
School of Pharmaceutical Sciences, Toho University
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Masaka Toru
School of Pharmaceutical Sciences, Toho University
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Matsuda Takuya
School of Pharmaceutical Sciences, Toho University
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Li Yingpeng
School of Pharmaceutical Sciences, Toho University
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Koide Yuki
School of Pharmaceutical Sciences, Toho University
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Takami Akira
School of Pharmaceutical Sciences, Toho University
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Imai Ryosuke
School of Pharmaceutical Sciences, Toho University
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Yagi Nobuhiro
School of Pharmaceutical Sciences, Toho University
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