Substituent Effects in the Fischer Indolization of (2-Sulfonyloxyphenyl)-hydrazones (Fischer Indolization and Related Compounds . XXX)
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概要
- 論文の詳細を見る
The effects of a variety of additional substituents of ethyl pyruvate 2-(2-methanesulfonyloxy)phenylhydrazone (7) in Fischer indolization were examined, When the substituent was a methyl group at the 3-, 4-, or 5-position, the yields of normal 7-methanesulfonyloxyindoles depended upon the position. The hydrazones having a methyl group at the position nearer to the methanesulfonyloxy group tended to give normal 7-methanesulfonyloxyindole in a higher percentage to total indolic products. In a series of 4-substituted phenylthydrazones (7d, e, f), more electron-withdrawing substituents tended to give normal 7-methanesulfonyloxyindole in a higher percentage to total indolic products than electron-donating ones. A hydrazone with a strong electron-withdrawing subsitiuent at the 4-position (7f) underwent intramolecular aromatic nucleophilic substitution by the enehydrazine moiety to give the cinnoline derivative.
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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渡辺 敏子
School Of Pharmaceutical Sciences Toho University
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Watanabe Toshifumi
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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Watanabe T
Chiba Univ. Chiba Jpn
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WATANABE Toshiko
Faculty of Pharmaceutical Sciences, Josai University
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Watanabe Toshiko
Faculty Of Pharmaceutical Sciences Chiba University
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Watanabe Toshiko
Graduate School Of Pharmaceutical Sciences Chiba University
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Watanabe Toshihiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Murakami Y
Toho Univ. Chiba Jpn
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MURAKAMI Yasuoki
School of Pharmaceutical Sciences, Toho University
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YOKOO Hiroshi
School of Pharmaceutical Sciences, Toho University
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YOKOYAMA Yuusaku
School of Pharmaceutical Sciences, Toho University
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Yokoyama Y
School Of Pharmaceutical Sciences Toho University
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Murakami Yasuoki
School Of Pharmaceutical Sciences Toho University
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Yokoo Hiroshi
School Of Pharmaceutical Sciences Toho University
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Yokoyama Yuusaku
School of Pharmaceutical Science, Toho University
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