Studies on the Chemical Constituents of Stem Bark of Millettia leucantha : Isolation of New Chalcones with Cytotoxic, Anti-herpes Simplex Virus and Anti-inflammatory Activities
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概要
- 論文の詳細を見る
Four new chalcone derivatives (1, 4, 7, 10) were isolated from the stem bark of millettia leucantha KURZ (Leguminosae) along with two known ones (2, 6) and five known flavones (3, 5, 8, 9, 11). Structure elucidation and unambiguous assignment of the isolates were achieved with the aid of 1D and 2D NMR extensive studies. Correlation of 10 to 4 was successfully done by reduction with Et_3SiH/CF_3CO_2H. Moderate cytotoxic activity was observed in chalcones (1, 10), whereas dihydrochalcones (4, 6) showed moderate anti-Herpes Simplex Virus (HSV) activity. Interestingly, flavone 8 showed significant anti-inflammatory effects inhibiting both cyclooxygenase (COX)-1 and -2.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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KIRTIKARA Kanyawim
National Center for Genetic Engineering and Biotechnology (BIOTEC)
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渡辺 敏子
School Of Pharmaceutical Sciences Toho University
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ISHIKAWA TSUTOMU
Graduate School of Pharmaceutical Sciences, Chiba University
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Kirtikara Kanyawim
タイ
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Kirtikara K
National Sci. And Technol. Dev. Agency (nstda) Bangkok Tha
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Kirtikara Kanyawim
National Center For Genetic Engineering And Biotechnology
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RUANGRUNGSI Nijsiri
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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WATANABE Toshiko
Graduate School of Pharmaceutical Science, Chiba University
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Watanabe Toshifumi
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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Ishikawa Tsutomu
Dep. Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Ishikawa Tsutomu
Graduate School Of Pharmaceutical Sciences Chiba University
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Watanabe Toshiko
Graduate School Of Pharmaceutical Sciences Chiba University
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Watanabe Toshiko
Faculty Of Pharmaceutical Sciences Josai University
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Watanabe Toshihiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Ishikawa T
Graduate School Of Pharmaceutical Sciences Chiba University
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PHRUTIVORAPONGKUL Ampai
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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LIPIPUN Vimolmas
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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NISHIKAWA Kiyohiro
Drug Research Department, R & D Division, Nippon Kayaku Co., Ltd.
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MARUYAMA Sakiko
Drug Research Department, R & D Division, Nippon Kayaku Co., Ltd.
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Maruyama Sakiko
Research & Development Group Nippon Kayaku Co. Ltd.
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Maruyama S
Drug Research Department R & D Division Nippon Kayaku Co. Ltd.
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Lipipun Vimolmas
Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Phrutivorapongkul Ampai
Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Ishikawa Tsutomu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Nishikawa K
Drug Research Department R & D Division Nippon Kayaku Co. Ltd.
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Ruangrungsi Nijsiri
Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Kirtikara Kanyawim
National Center For Genetic Engineering And Biotechnology (biotec) Tha
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Watanabe Toshiko
Graduate School Of Pharmaceutical Science Chiba University
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Ishikawa Toshihisa
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
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Ishikawa Toshihisa
Graduate School of Pharmaceutical Sciences, Chiba University
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