Fischer Indolization of Variously ortho-Substituted Phenylhydrazones (Fischer Indolization and Its Related Compounds. XXV)

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概要

• 論文の詳細を見る

• Various kinds of ethyl pyruvate 2-(2-substituted phenyl)hydrazones (1) were subjected to Fischer indolization with acid catalysts. All the phenylhydrazones gave corresponding normal 7-substituted indoles (2). In addition, phenyl-hydrazones whose ortho-substituent is electron-donative or has a central atom with an unshared electron pair tended to give the 4- or 5-substituted indole (3), which was produced by migration of the ortho-substituent during cyclization, whereas those whose ortho-substituent is electron-attractive tended to give little or no such abnormal product. The kind of acid catalyst used had some effect on the yield ratio of products but not on the kind of products.

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 石井 永

  Faculty of Pharmaceutical Sciences, Chiba University

• 渡辺 敏子

  千葉大院薬

• 高橋 朋子

  School Of Pharmaceutical Sciences Toho University

• 阿刀田 英子

  Faculty Of Pharmaceutical Sciences Chiba University

• 渡辺 敏子

  School Of Pharmaceutical Sciences Toho University

• 石井 永

  Faculty Of Pharmaceutical Sciences Chiba University

• 横山 祐作

  School of Pharmaceutical Sciences, Toho University

• 村上 泰興

  School of Pharmaceutical Sciences, Toho University

• 直町 純子

  School of Pharmaceutical Sciences, Toho University

• 岩瀬 治雄

  School of Pharmaceutical Sciences, Toho University

• 渡辺 紀子

  School of Pharmaceutical Sciences, Toho University

• 森畑 美智代

  School of Pharmaceutical Sciences, Toho University

• 奥山 直美

  School of Pharmaceutical Sciences, Toho University

• 鎌倉 浩之

  School of Pharmaceutical Sciences, Toho University

• 東條 俊明

  Faculty of Pharmaceutical Sciences, Chiba University

• 森田 憲司

  Faculty of Pharmaceutical Sciences, Chiba University

• Murakami Yukihisa

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Mukarami Yukihisa

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Murakami Yukihisa

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Murakami Yukihisa

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)

• 森畑 美智代

  School Of Pharmaceutical Sciences Toho University

• Watanabe Toshifumi

  Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries

• Watanabe T

  Chiba Univ. Chiba Jpn

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Chiba University

• Watanabe Toshiko

  Graduate School Of Pharmaceutical Sciences Chiba University

• Watanabe Toshihiro

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Murakami Y

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Ishii H

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 東條 俊明

  Faculty Of Pharmaceutical Sciences Chiba University

• 渡辺 紀子

  School Of Pharmaceutical Sciences Toho University

• 村上 泰興

  School Of Pharmaceutical Science Toho University

• 横山 祐作

  東邦大学薬学部

• 鎌倉 浩之

  School Of Pharmaceutical Sciences Toho University

• 奥山 直美

  School Of Pharmaceutical Sciences Toho University

• 岩瀬 治雄

  School Of Pharmaceutical Sciences Toho University

• 直町 純子

  School Of Pharmaceutical Sciences Toho University

• 森田 憲司

  Faculty Of Pharmaceutical Sciences Chiba University

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