Studies on Lysergic Acid Diethylamide and Related Compounds. VII. Microbial Transformation of Lysergic Acid Diethylamide and Related Compounds
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概要
- 論文の詳細を見る
Lysergic acid diethylamide (LSD) was biotransformed by various species of microorganisms to give four metabolites ; lysergic acid ethylamide (LAE), and norlysergic acid diethylamide (norLSD) are already known, but lysergic acid ethyl-2-hydroxyethylamide (LEO) and lysergic acid ethylvinylamide (LEV) have not been reported previously. Characteristic features of Streptomyces roseochromogenes and S. lavendulae were noted in biotransformation experiments with LSD and isoLSD. The latter has an enzyme system for the demethylation of LSD and isoLSD, but the former does not. Using the technique of reincubation of metabolites, the metabolic pathway from LSD to LEV or LEO in S. roseochromogenes was studied, and the pathway of biotransformation from LEV to LEO was established.
- 公益社団法人日本薬学会の論文
- 1979-07-25
著者
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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林 誠
Research Institute For Chemobiodynamics Chiba University
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丹羽口 徹吉
National Research Institute of Police Science
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中原 雄二
National Research Institute of Police Science
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中原 雄二
National Institute Of Health Sciences
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