高次有機銅試薬を用いるgem-ジブロモシクロプロパン体のアルキル化反応について
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概要
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The reaction of gem-dibromocyclopropanes (1) with a higher-order organocuprate prepared from CuCN and commercially available MeLi, followed by the addition of MeI in situ, afforded dimethylcyclopropanes (2) in good yields. The differential substitution reaction of dibromide (1a) in one pot with the higher-order organocuprate and allyl bromide gave a compound (8) in the moderate selectivity as shown in Table 3. Its stereochemistry was deduced by the reaction mechanism.
- 社団法人日本薬学会の論文
- 1995-10-25
著者
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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原山 尚
岡山大学薬学部
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原山 尚
Faculty Of Pharmaceutical Sciences Kyoto University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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小林 英夫
岡山大学薬学部
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西田 寛子
千葉大学薬学部
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石井 永
千葉大学薬学部
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