Fischer Indolization and Its Related Compounds. VIII. Formation of 4-Aminoindole Derivatives on the Fischer Indolization of 2-Methoxyphenylhydrazone Derivatives
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概要
- 論文の詳細を見る
Fischer indolization of ethyl pyruvate 5-chloro-2-methoxyphenylhydrazone (6) with anhydrous zinc chloride gave ethyl 4-amino-6-chloroindole-2-carboxylate (12) as a main product, with three other expected in doles, (7), (8) and (5). Cyclization of ethyl pyruvate 2-methoxyphenylhydrazone (1) with p-toluenesulfonic acid in the presence of diethyl malonate afforded ethyl 4-(ethoxycarbonylacetamido)-indole-2-carboxylate (28) and diethyl 4-(ethoxycarbonylacetamido)-3,6'-biindole-2,2'-dicarboxylate (30) with five other indole derivatives, (11), (10), (26), (27), and (32). The pathway leading to such a 4-aminoindole product in the abnormal Fischer indolization of a 2-methoxyphenylhydrazone derivative is discussed.
- 社団法人日本薬学会の論文
- 1974-09-25
著者
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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村上 泰興
Faculty of Pharmaceutical Sciences, University of Tokyo
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古瀬 徳夫
Faculty Of Pharmaceutical Sciences Chiba University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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武田 春樹
Faculty of Pharmaceutical Sciences, Chiba University
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村上 泰興
東邦大・薬
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武田 春樹
Faculty Of Pharmaceutical Sciences Chiba University
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