Re-examination of the Synthesis of 7,8-Dimethoxy-2-methyl-3-(4', 5'-methylenedioxy-2'-vinylphenyl)iso carbostyril

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概要

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• Oxidation of the enamine (6) to the isocarbostyril (7) was re-examined. Simply stirring a dimethylformamide (DMF) solution of 6 provided 7 with good reproducibility, in the presence of KCN under an oxygen atmosphere. The structure of the chloroform adduct (8) was determined by an X-ray analysis.

• 社団法人日本薬学会の論文
• 1991-10-25

著者

• 石井 永

  Faculty of Pharmaceutical Sciences, Chiba University

• 武田 直

  Faculty of Pharmaceutical Sciences, Chiba University

• 原山 尚

  Faculty of Pharmaceutical Sciences, Chiba University

• 緒方 惟治

  The Chemical Analysis Center Chiba University

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• 石井 永

  Faculty Of Pharmaceutical Sciences Chiba University

• 花岡 美代次

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 武田 直

  Faculty Of Pharmaceutical Sciences Chiba University

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