Oxidation of Pyrimidine Base Derivatives with m-Chloroperbenzoic Acid

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概要

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• Oxidations of 1,3-dimethylthymine (1), 3', 5'-diacetylthymidine (2), 1,3-dimethyluracil (3), 5-fluoro-1,3-dimethyluracil (4), and 2', 3', 5'-triacetyluridine (5) with m-chloroperbenzoic acid were investigated. Dimethylthymine (1) gave the hydroxy ester (6), the stereostructure of which was determined by an X-ray analysis, while diacetylthymidine (2) gave 10a and 10b. Dimethyluracil (3) provided 11,12,and 13,and 5-fluoro-dimethyluracil (4) provided 11. Triacetyluridine (5) afforded 16 in dichloromethane and 17 in benzene. A plausible mechanism for formation of these oxidation products is presented.

• 公益社団法人日本薬学会の論文
• 1986-06-25

著者

• 原山 尚

  Faculty of Pharmaceutical Sciences, Chiba University

• 米田 文郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 多賀 徹

  Faculty of Pharmaceutical Sciences, Kyoto University

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• 柳田 玲子

  Faculty of Pharmaceutical Sciences, Kyoto University

• 永松 朝文

  Faculty of Pharmaceutical Sciences, Okayama University

• 大崎 健次

  Faculty of Pharmaceutical Sciences, Kyoto University

• 多賀 徹

  京大・薬

• 柳田 玲子

  京都大学薬学部

• 柳田 玲子

  Faculty Of Pharmaceutical Sciences Setsunan University

• 米田 文郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 多賀 徹

  京大・院薬・薬品分子構造

• 多賀 徹

  Faculty Of Pharmaceutical Sciences Kyoto University

• [コト]子 佳代子

  Faculty of Pharmaceutial Sciences, Kyoto University

• 永松 朝文

  Faculty Of Pharmaceutical Sciences Okayama University

• 大崎 健次

  Faculty Of Pharmaceutical Sciences Kyoto University

• 事子 佳代子

  Faculty Of Pharmaceutial Sciences Kyoto University

• 大崎 健次

  Faculty of Pharmaceutial Sciences, Kyoto University

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