Synthesis of 1,3-Dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H)-diones (1,3-Dimethyl-5-deazaalloxazines) and Related Compounds via the Intramolecular Cycloaddition of Azahexatrienes

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概要

• 論文の詳細を見る

• Heating of 6-arylamino-1,3-dimethyluracils (IIa-e) with one-carbon reagents (dimethylformamide dimethylacetal, dimethylformamide-phosphorus oxychloride, and triethyl orthoformate) afforded 1,3-dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H)-diones (Va-e) via the intramolecular cycloaddition of azahexatrienes. Similarly, treatment of IIa with arylaldehydes provided 5-aryl-1,3-dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H, 5H, 10H)-diones (VIIa-e), which were subsequently dehydrogenated with either thionyl chloride or diethyl azodicarboxylate to give 5-aryl-1,3-dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H)-diones (Xa-e). The reaction of 6-arylamino-1,3-dimethyl-4-N-phenylcytosines (XIIa-c) with dimethylformamide dimethylacetal to give 4-arylimino-1,3-dimethylpyrimido [4,5-b] quinoline-2 (1H, 3H)-ones (XIIIa-c) is also described.

• 公益社団法人日本薬学会の論文
• 1980-01-25

著者

• 佐藤 純子

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 米田 文郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 千賀 慶太郎

  Pharmaceutical Institute, School of Medicine, Keio, University

• 千賀 慶太郎

  Pharmaceutical Institute School Of Medicine Keio University

• 千賀 慶太郎

  慶応大 病院

• 千賀 慶太郎

  慶応義塾大学病院薬剤部

• 米田 文郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 西垣 貞男

  Pharmaceutical Institute School Of Medicine Keio University

• 西垣 貞雄

  Pharmaceutical Institute School Of Medicine Keio University

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