Syntheses and Properties of 4-Deazatoxoflavins and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of 6-(1-methylhydrazino) uracil (I) with phenacyl bromides in methoxyethanol afforded the corresponding 3-aryl-1-methylpyrimido [4,5-c] pyridazine-5,7 (1H, 6H)-diones (3-aryl-6-demethyl-4-deazatoxoflavins) (II) and 3-aryl-5,7-dioxo-1-methyl-1,4,5,6,7-pentahydropyrimido [4,3-c] [1,2,4] triazines (III). Methylation of II and III with methyl iodide gave the corresponding 3-aryl-4-deazatoxoflavins (IV) and 1,6-dimethyl-5,7-dioxopyrimido [4,3-c] [1,2,4] triazines (V). The reaction of IV with m-chloroperbenzoic acid in chloroform gave the corresponding 3-aryl-4,4a-epoxy-4-deazatoxoflavins (VI). The oxidizing abilities of II toward alcohols were examined in comparison with those of IV from both kinetic and synthetic viewpoints. Treatment of IV with 30% aqueous caustic alkali led to the exclusive formation of 4,8-dihydro-4-deazatoxoflavins (VII) and 4,8-dihydro-4-deazatoxoflavin-4-ones (VIII) via intermolecular oxidation-reduction between the initially formed 4-hydroxy-4,8-dihydro-4-deazatoxoflavins (IX) and unchanged IV. Treatment of VI with 10% aqueous sodium hydroxide gave the 6-aryl-4-hydroxy-2-methylpyridazine-3 (2H)-ones (X).
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
-
米田 文郎
Faculty of Pharmaceutical Sciences, Kyoto University
-
神代 昭
山口大学医学部附属病院薬剤部
-
播磨 由紀子
山口大学医学部附属病院薬剤部
-
藤田 俊生
The Department Of Pharmacy Yamaguchi University Hospital
-
神代 昭
Department Of Pharmaceutics Niigata College Of Pharmacy
-
中川 敬士
Faculty of Pharmaceutical Sciences, Kumamoto University
-
藤田 俊生
Department of Pharmacy, Yamaguchi University Hospital
-
播磨 由起子
Department of Pharmacy, Yamaguchi University Hospital
-
米田 文郎
Faculty Of Pharmaceutical Sciences Kyoto University
-
中川 敬士
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- An Efficient Method for Preparing gem-Dimethylcyclopropanes from gem-Dibromocyclopropanes(Organic,Chemical)
- Reaction of 8,8-DibromobicycJo[5.1.0]octanes with Higher-Order Organocuprates(Organic,Chemical)
- AN EFFICIENT METHOD FOR PREPARING GEM-DIMETHYLCYCLOPLOPANES FROM GEM-DIBROMOCYCLOPROPANES
- スピロベチバン型セスキテルペンの形式合成
- CHEMILUMINESCENT REACTIONS OF "UNMODIFIED" FLAVINS
- Riboflavin-Sensitized Photooxidation of Phenothiazines in Aqueous Solution by Laser-Irradiation
- Brompton MiXtureの微生物汚染対策
- 調剤用水の微生物学的検討
- 各種輸液中におけるブドウ糖非発酵グラム陰性桿菌の動態
- 新生児用5%果糖液の微生物汚染例
- クロルヘキシジンと低濃度エタノールとの併用による消毒効果
- 輸液中における硫酸ゲンタマイシン注射液の配合性
- On the Repair of Thymine and Thymidine Bromohydrins : A Possible New Model for the Damage and Repair of Nucleic Acids
- Syntheses of 3-Substituted 1-Methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H, 6H)-diones (6-Phenyl Analogs of Toxoflavin) and Their 4-Oxides, and Evaluation of Antimicrobial Activity of Toxoflavins and Their Analogs
- THE INHIBITION OF THE PHOTOCHEMICAL DIMERIZATION OF 1,3-DIMETHYLTHMINE BY FLAVIN AND 5-DEZAFLAVIN DERIVATIVES
- ABC分析を利用したパソコンによる薬品管理システム
- Synthesis of Chiral 5-Deazaflavin Derivatives and Their Use in Asymmetric Reduction of Ethyl Benzoylformate(Organic,Chemical)
- Pharmacokinetic and Pharmacodynamic Studies of Centrally Acting Drugs in Rat : Effect of Pentobarbital and Chlorpromazine on Electroencephalogram in Rat
- Pharmacokinetic and Pharmacodynamic Studies of Chlorpromazine in Rats : Effect of Chlorpromazine on Dopamine and Dopamine Metabolite Concentration in Rat Striatum
- Pharmacokinetic Analysis of Chlorpromazine in Rat Serum, Cerebrospinal Fluid and Striatum
- Protein Binding of Chlorpromazine in Vivo and in Vitro : Effect of Chlorpromazine Metabolite on Chlorpromazine Protein Binding in Rat
- Pharmacokinetic and Pharmacodynamic Studies of L-Dopa in Rats. II. Effect of L-Dopa on Dopamine and Dopamine Metabolite Concentration in Rat Striatum
- Pharmacokinetic and Pharmacodynamic Studies of L-Dopa in Rats. I. Pharmacokinetic Analysis of L-Dopa in Rat Plasma and Striatum
- CONVENIENT SYNTHESES OF OLIGONUCLEOTIDES LINKED TO 5-DEAZAFLAVIN COENZYME MODELS AT 3'-END. INCORPORATION OF 5-DEAZAFLAVIN TO CONTROLLED PORE GLASS(CPG) SUPPORT
- THE CHEMICAL REPAIR REACTION OF THYMINE AND THYMIDINE DIOL DERIVATIVES, MODELS OF OXIDATIVELY DAMAGED NUCLEIC ACIDS, BY TRIVALENT PHOSPHORUS COMPOUNDS
- THE REDUCTIVE REPAIR OF ADENINE-1-OXIDE DERIVATIVES TO ADENINE DERIVATIVES BY γ-GLUTAMYLCYSTEINYLGLYCINE (GLUTATHIONE)
- REDOX POTENTIAL OF OLIGONUCLEOTIDE LINKED TO 5-DEAZAFLAVIN COENZYME MODEL. DETECTION OF HYBRID FORMATION BY CYCLIC VOLTAMMOMETRY
- HYBRIDIZATION OF OLIGODEOXYNUCLEOTIDE WITH REXOD COENZYME MODEL; SYNTHESIS AND PROPERTIES OF THYMIDINE DECAMERS COVALENTLY LINKED TO 5-DEAZAFLAVIN
- チミジンリン酸エステルのブロムヒドリンのチミジンリン酸エステルへの変換について : チミジンヌクレオチドの酸化損傷体の修復に関するモデル反応
- Kinetics and Mechanism of Degradation and automerization of Cefotetan in Aqueous Solution
- ヒノキチオールおよび7-ヨードヒノキチオールのメチル化とヒドラジノトロポン誘導体および5-アミノヒノキチオールのSchiff塩基の合成
- Syntheses and Properties of 4-Deazatoxoflavins and Related Compounds
- Synthesis of 10-Arylpyrimido [4,5-b] quinoline-2,4 (3H, 10H) diones (10-Aryl-5-deazaflavins) and Their Use in Oxidations of Alcohols and Amines
- A New Synthesis of Pyrimido [4,5-b] quinoline-2,4 (1H, 3H) diones (5-Deazaalloxazines) by Oxidative Cyclization of Aryl-bis (6-amino-1,3-dimethyluracil-5-yl)-methanes with Diethyl Azodicarboxylate
- 調剤におけるContamination防止とその対策
- 内服用カリウム製剤の溶出
- 泌尿器科における術後の細菌尿の実態
- Synthesis of 1,3-Dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H)-diones (1,3-Dimethyl-5-deazaalloxazines) and Related Compounds via the Intramolecular Cycloaddition of Azahexatrienes
- 夢コレクションPart2
- SYNTHESIS OF A 5-DEAZA-10-SELENAFLAVIN DERIVATIVE, A NEW TYPE OF 5-DEAZAFLAVIN REDOX COENZYME MODEL
- Asymmetric Reduction with 5-Deazaflavin. III. : Reduction of Ethyl Benzoylformate in the Presence of Chiral Ligand
- A New Synthetic Approach to 5-Deazaflavin and 5- Deaza-10-thiaflavin
- Asymmetric Reduction with 5-Deazaflavin. II. : Synthesis of Some Chiral 5-Deazaflavin Derivatives
- Simple New Method for the Synthesis of 5-Deaza-10-oxaflavin, a Potential Organic Oxidant
- ONE-POT UNSYMMETRICAL DOUBLE SUBSTITUTION OF 8,8-DIBROMOBICYCLO[5.1.0]OCTANE AND ITS STEREOCEHMISTRY
- 5-Arylidene 1,3-Dimethylbarbituric Acid Derivatives, Mild Organic Oxidants for Allylic and Benzylic Alcohols
- Stereo-Structures of Reaction Products of dl-1,3-Dimethylthymine Epoxide with Amines and L-Amino Acid Ethyl Esters(Organic,Chemical)
- Oxidation of Pyrimidine Base Derivatives with m-Chloroperbenzoic Acid
- OXIDATION OF 1,3-DIMETHYL DERIVATIVES OF PYRIMIDINE BASES WITH m-CHLOROPERBENZOIC ACID
- Flomoxefの水溶液及び5%ブドウ糖配合注射液中での安定性
- ラタモキセフ2ナトリウムの水溶液及び5%ブドウ糖配合注射液中での安定性
- Kinetics and Mechanism of the Degradation and Epimerization of Sodium Cefsulodin in Aqueous Solution
- セファセトリルナトリウム注射剤の配合変化
- Kinetic Study of the Degradation of Cefotiam Dihydrochloride in Aqueous Solution and of the Reaction with Aminoglycosides
- Tegafur (1-(2-Tetrahydrofuryl)-5-fluorouracil) のミクロ液体クロマトグラフィーによる定量
- Syntheses and Properties of 3-Hydroxy-4,6-dimethylpyrrolo [3,2-d] pyrimidine-5,7 (4H, 6H)-dione (9-Hydroxy-9-deazatheophylline) Derivatives
- 1,3-ジメチルチミンエポキシドとアミン類との反応における溶媒効果(有機化学)
- MILD OXIDATION OF ALLYLIC AND BENZYLIC ALCOHOLS WITH 5-ARYLIDENE BARBITURIC ACID DERIVATIVES AS A MODEL OF REDOX COENZYMES
- Syntheses of Isoalloxazines. A New Synthesis of Riboflavin
- The Novel Use of Diethyl Azodicarboxylate in a New Synthesis of 7-Azapteridine-N-oxides
- 1,3,8,10,11,14-HEXAZAPENTAPHENE-2,4,7,9(14H___-, 3H___-, 8H___-, 11H___-)-TETRAONES (BENT DOUBLE-HEADED 5-DEAZAFLAVINS) WITH STRONG OXIDIZING POWER
- A CONVENIENT LEWIS ACID CATALYZED PREPARATION OF CARBAMATES FROM SECONDARY ALCOHOLS AND ISOCYANATES
- FORMATION OF 4a, 5-DIHYDRO-4a-HYDROXY-5-DEAZAFLAVINS IN THE REACTION OF 1,5-DIHYDRO-5-DEAZAFLAVINS WITH m-CHLOROPERBENZOIC ACID AND THEIR PYRIMIDINE RING CONTRACTION WITH BASE
- ペントキシフィリン錠の品質比較
- A Synthesis of Alloxazine 5-Oxides by the Reaction of 6-Anilinouracils with Nitric Acid and 4-Phenylurazole
- Nitrosative and Nitrative Cyclizations of 6-Benzylamino-1,3-dimethyl-4-N-phenylcytosine
- A New Synthetic Approach to 8-Chloroflavins and Their Conversion into 8-(Substituted-amino) flavins
- SYNTHESIS AND PROPERTIES OF A NEW CLASS OF PYRIDODIPYRIMIDINES, 8-ALKOXYPYRIDO [2,3-d : 6,5-d'] DIPYRIMIDINE-2,4,6 (3H, 10H, 7H)-TRIONES
- 市販錠剤およびカプセル剤の重量、崩壊時間および硬度の解析
- Syntheses and Properties of Some Pyrrolo[2,3-d]pyrimidine Derivatives
- Dimethylamination and Nitrosation of Pyrimidines with N-Nitrosodimethylamine
- Intermolecular Dimethylamination and Nitrosation with N-Nitrosodimethylamine
- A Novel Synthesis of 6-Deoxytheophyllines and 6-Deoxy-7-deazatheophyllines
- Thio-analogues of 6-Substituted 1,3-Dimethyl-7-azalumazine (Fervenulin) and 7-Substituted 1,3-Dimethyl-6-azalumazine (Isofervenulin)
- The Syntheses of Some Androstano [2,3-g] pteridines
- Syntheses of 1,6-Dimethylpyrimido [4,5-c] pyridazine-5,7 (1H, 6H)-diones (4-Deazatoxoflavins) and Their Use in the Autorecycling Oxidation of Alcohols and Amines
- Syntheses of Heterocycles via Intramolecular Cycloaddition of Azahexatrienes. Photochemical Cyclization of 5-Arylazo-6-dimethylaminomethyleneamino-1,3-dimethyluracils
- Syntheses of Substituted 8-Aminopurine Derivatives
- Novel Ring Expansions of Pyrrolo-pyrimidines to Pyrimido-pyrimidines
- Syntheses of 4-Methyl-s-triazolo [4,3-a] purin-9 (4H)-ones and Tetrazolo-[1,5-a] purin-9 (4H)-ones as Aza Analogs of "Y"Bases
- Synthesis and Properties of 2,3,4,8-Tetrahydro-2,4-dioxopyrido [2,3-d]-pyrimidines (5-Deazalumazines) and Their Bis-compounds
- Synthesis and Properties of 3,4-Disubstituted 1-Methylpyrimido [4,5-c] pyridazine-5,7 (1H, 6H)-diones (3,4-Disubstituted 4-Deazatoxoflavins) and 3,4-Disubstituted 4-Deazatoxoflavin Bound to Polystyrene and Their Use in Autorecycling Oxidation of Amines
- A Convenient Synthesis of Toxoflavins, Toxoflavin 4-Oxides and 1-Demethyltoxoflavins
- Cyclization Reactions of Some 5-Nitro- and 5-Nitroso-6-benzylidenehydrazinouracils
- Heterocycle N-Oxide Synthesis by the Nitrative Cyclization. New Syntheses of Fervenulin N-Oxide, Alloxazine N-Oxide, Isoalloxazine N-Oxide and Purine N-Oxide
- アトック^錠の品質試験とアトック^ドライシロップの安定性及び配合試験
- A Novel One-step Synthesis of Tricycloquinazolines
- Reaction of 5,6-Diamino-1,3-dimethyluracil with Isatoic Anhydrides
- 新しい現象との邂逅を求めて(研究の断念と新テーマの着手-研究の決断-)
- 業務と研究の調和の上に薬学臨床応用の場の開拓を(薬局・薬剤部における研究のあり方)
- ペプシン処理ヒト免疫グロブリンと抗生剤のin vitro併用効果〔英文〕
- Cisplatin の静脈および動脈投与時の体内動態
- INFLUENCE OF SYNTHETIC ATP ON DYE EXCRETING FUNCTION OF THE LIVER IN ATP DEFICIENT RAT