Synthesis of Chiral 5-Deazaflavin Derivatives and Their Use in Asymmetric Reduction of Ethyl Benzoylformate(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Some 1, 5-dihydro-5-deazaflavin (1, 5-dihydropyrimido [4, 5-b>] quinoline-2, 4(3H, 10H)-dione) derivatives possessing chiral substituents at the N-3 position were synthesized. Asymmetric reduction of ethyl benzoylformate in the presence of magnesium perchlorate was carried out with these chiral 1, 5-dihydro-5-deazafiavin derivatives to give ethyl mandelate in moderate optical and chemical yield. The influence of metal additives other than magnesium upon the asymmetric induction and yield of the reduction was investigated, and it was suggested that intermediate ternary complexation is probably involved in the reaction. No improvement of chiral induction was obtained by changing the metal catalyst.
- 社団法人日本薬学会の論文
- 1987-04-25
著者
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米田 文郎
Faculty of Pharmaceutical Sciences, Kyoto University
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田中 圭
Faculty Of Pharmaceutical Sciences Kyoto University
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田中 圭
静岡県大 薬
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岡田 知也
Faculty Of Pharmaceutical Sciences Kyoto University
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陳 星
Faculty Of Pharmaceutical Sciences Kyoto University
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木村 禎治
Faculty of Pharmaceutical Sciences, Kyoto University
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米田 文郎
Faculty Of Pharmaceutical Sciences Kyoto University
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木村 禎治
Faculty Of Pharmaceutical Sciences Kyoto University
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田中 圭
京都大学薬学部
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田中 圭
Faculty of Eng., Oita Univ.
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