A Synthesis of Alloxazine 5-Oxides by the Reaction of 6-Anilinouracils with Nitric Acid and 4-Phenylurazole
スポンサーリンク
概要
- 論文の詳細を見る
The treatment of 6-anilinouracils with a mixture of nitric acid and 4-phenylurazole (which is virtually a mixture of nitrous acid and 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD)) in dioxane gave the corresponding alloxazine 5-oxides exclusively. This reaction involves the nitrosative cyclization of 6-anilinouracils by nitrous acid, followed by the dehydrogenation of the hydroxylamine intermediates with PTAD. 6-Anilinouracils react with PTAD to give the corresponding Michael-type adducts, 6-anilino-5-(4-phenylurazol-1-yl) uracils.
- 公益社団法人日本薬学会の論文
- 1975-10-25
著者
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松本 茂
Faculty Of Pharmaceutical Sciences Osaka University
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米田 文郎
Faculty Of Pharmaceutical Sciences Kyoto University
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佐久間 義治
Faculty of Pharmaceutical Sciences, Kumamoto University
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佐久間 義治
Faculty Of Pharmaceutical Sciences Kumamoto University
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