A Novel Synthesis of 6-Deoxytheophyllines and 6-Deoxy-7-deazatheophyllines

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概要

• 論文の詳細を見る

• The reaction of 8-phenyl-7-deazatheophyllines (I) with phosphorus oxychloride gave 6-chloro-6-deoxy-8-phenyl-7-deazatheophyllines (II) in high yields. Compounds II served as useful starting materials for several nucleophilic reactions. The reaction of I with phosphorus oxychloride in the presence of amines has been carried out to succeed in obtaining the corresponding 6-amino-derivatives in a single step. The reaction of 8-phenyl-theophylline (III) with phosphrous oxychloride gave 6-chloro-6-deoxy-8-phenyltheophylline (IV) in good yield. 6-Substituted 6-deoxy-8-phenyltheophyllines were prepared by the reaction of III with phosphorus oxychloride in the presence of amines in a single step. The reaction of I (or III) with phosphorus oxychloride essentially involves the conversion of aminoenketone (or aminoazadienketone) to iminoenchloride (or iminoazadienchloride).

• 公益社団法人日本薬学会の論文
• 1972-07-25

著者

• 千賀 慶太郎

  慶応大 病院

• 千賀 慶太郎

  慶応義塾大学病院薬剤部

• 米田 文郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 樋口 昌嗣

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 西垣 貞男

  Pharmaceutical Institute School Of Medicine Keio University

• 西垣 貞雄

  Pharmaceutical Institute School Of Medicine Keio University

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