A New, Facile Synthesis of Oxazolo [5,4-d] pyrimidines and Their Conversion into Thiazolo [5,4-d] pyrimidines

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概要

• 論文の詳細を見る

• The condensation of 5-amino-1,3-dimethylbarbituric acid (I) with aromatic aldehydes gave 5-benzylideneamino-1,3-dimethylbarbituric acids (II). Treatment of (II) with thionyl chloride afforded 2-aryl-5,7-dimethyloxazolo [5,4-d] pyrimidine-4,6 (5H, 7H)-diones (IV) in good yields. The reaction of (IV) with phosphorus pentasulfide in pyridine provided 2-aryl-5,7-dimethylthiazolo [5,4-d] pyrimidine-4 (5H)-one-6 (7H)-thiones (VI), which were then converted to 2-aryl-5,7-dimethylthiazolo [5,4-d] pyrimidine-4,6 (5H, 7H)-diones (VII) by the action of 30% hydrogen peroxide in acetic acid or thionyl chloride.

• 公益社団法人日本薬学会の論文
• 1978-03-25

著者

• 佐藤 純子

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 千賀 慶太郎

  Pharmaceutical Institute, School of Medicine, Keio, University

• 千賀 慶太郎

  Pharmaceutical Institute School Of Medicine Keio University

• 千賀 慶太郎

  慶応大 病院

• 千賀 慶太郎

  慶応義塾大学病院薬剤部

• 西垣 貞男

  Pharmaceutical Institute, School of Medicine, Keio University

• 佐藤 純子

  Pharmaceutical Institute, School of Medicine, Keio University

• 西垣 貞男

  Pharmaceutical Institute School Of Medicine Keio University

• 西垣 貞男

  慶応義塾大学病院

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