Condensation Reactions of Ethyl Ethoxymethylenecyanoacetate with Amidines

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概要

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• The pyrimidine synthesis from ethyl ethoxymethylenecyanoacetate (EMCE) and amidines is significantly influenced by the mole ratios of reacting components. In general the use of excess amidine gives better yields. Condensation of EMCE with excess acetamidine gives 4-hydroxy-2-methyl-5-pyrimidinecarbonitrile acetamidinate as the main product in good yield. Reaction between EMCE and excess 2-ethyl-2-thiopseudourea gives 2-ethylthio-4-hydroxy-5-pyrimidinecarbonitrile 2-ethyl-2-thiopseudoureate rather than 3-{3-{[amino (ethylthio) methylene] amino}-2-cyanoacryloyl}-2-ethyl-2-thiopseudourea originally claimed. The condensation reactions of EMCE with other amidines such as guanidine and benzamidine have been studied.

• 公益社団法人日本薬学会の論文
• 1970-05-25

著者

• 千賀 慶太郎

  Pharmaceutical Institute School Of Medicine Keio University

• 千賀 慶太郎

  慶応大 病院

• 千賀 慶太郎

  慶応義塾大学病院薬剤部

• 米田 文郎

  Pharmaceutical Sciences, Kumamoto University

• 西垣 貞雄

  Pharmaceutical Institute School Of Medicine Keio University

• 相田 京子

  Pharmaceutical Institute, School of Medicine, Keio University

• 高畠 豊実

  Pharmaceutical Institute, School of Medicine, Keio University

• 相田 京子

  Pharmaceutical Institute School Of Medicine Keio University

• 高畠 豊実

  Pharmaceutical Institute School Of Medicine Keio University

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