Nitrosative Cyclization of 1,3-Dimethyl-6-(α-methylalkylidenehydrazino)-uracils by Means of N-Nitrosodimethylamine-Phosphorus Oxychloride Mixture. A New Route to 2-Vinyl-v-triazolo [4,5-d] pyrimidines
スポンサーリンク
概要
- 論文の詳細を見る
A new synthetic method of 2-vinyl-v-triazolo [4,5-d] pyrimidines, which consists of the nitrosative cyclization of 1,3-dimethyl-6-(α-methylalkylidenehydrazino) uracils with a mixture of N-nitrosodimethylamine and phosphorus oxychloride (NDA+POCl_3) is described. The reaction of 1,3-dimethyl-6-hydrazino-5-nitrosouracil with acetophenone gave 1,3-dimethyl-6-phenyl-7-azalumazine (3-phenylfervenulin) (X). The nitrosation of 6-benzylidenehydrazino-1,3-dimethyluracil with NDA+POCl_3 also gave X.
- 公益社団法人日本薬学会の論文
- 1976-08-25
著者
-
千賀 慶太郎
慶応大 病院
-
千賀 慶太郎
慶応義塾大学病院薬剤部
-
西垣 貞男
Pharmaceutical Institute, School of Medicine, Keio University
-
金森 由香子
Pharmaceutical Institute, School of Medicine, Keio University
-
金森 由香子
Pharmaceutical Institute School Of Medicine Keio University
-
米田 文郎
Pharmaceutical Sciences, Kumamoto University
-
西垣 貞男
Pharmaceutical Institute School Of Medicine Keio University
-
西垣 貞雄
Pharmaceutical Institute School Of Medicine Keio University
関連論文
- 1,3-Dipolar Cycloaddition Reactions of Thiazolo[5,4-d]pyrimidine 1-0xides with Acetylenic Esters Involving New Ring Transformations of the Thiazole Nucleus(Organic,Chemical)
- 硫酸サルブタモール錠の粉砕後の安定性
- THE CRYSTAL STRUCTURE OF FTORAFUR
- Synthetic Antibacterials. VII. N-(1,8-Naphthyridin-7-yl)-methylenamine Derivatives
- Synthetic Antibacterials. VI. 7-[1-Substituted 2-(5-nitro-2-furyl) vinyl]-1,8-naphthyridines
- 遺伝子組換えヒトエリスロポエチン注射液の配合試験
- 高速液体クロマトグラフ法による人血漿,胆汁,尿中クリンダマイシンの定量
- 慶應義塾大学病院における残置薬および廃棄薬の発生とその要因解析
- NEW DEGRADATION PRODUCTS IN AN AQUEOUS SOLUTION OF HYDRALAZINE HYDROCHLORIDE WITH CIMETIDINE
- A NEW RING TRANSFORMATION OF THIAZOLO[4,5-g]QUINAZOLINE 3-OXIDES INTO [1,4]THIAZINO[3,2-g]QUINAZOLINES BY THE 1,3-DIPOLAR CYCLOADDITION REACTION
- 光学,蛍光並びに偏光顕微鏡による医薬品の同定 : 調剤室における落下及び浮遊粉じん中の薬物(医薬品の分析)
- Synthesis of 9-Substituted 8-Phenyltheophyllines
- Synthesis of 1,3-Dimethylpyrimido [4,5-b] quinoline-2,4 (1H, 3H)-diones (1,3-Dimethyl-5-deazaalloxazines) and Related Compounds via the Intramolecular Cycloaddition of Azahexatrienes
- Conversion of 6-Benzylidenehydrazino-1,3-dimethyluracils into N^4-Benzylideneamino-1,3-dimethylcytosines
- A New, Facile Synthesis of Oxazolo [5,4-d] pyrimidines and Their Conversion into Thiazolo [5,4-d] pyrimidines
- Syntheses of 9-Deazatheophyllines and 6-Deoxy-9-deazatheophyllines
- Oxidative Cyclization of 6-Substituted Amino-5-benzylideneamino-1,3-dimethyluracils to 9-Substituted 8-Aryltheophyllines with Thionyl Chloride
- Synthesis of Xanthines by Dehydrogenative Cyclization of 6-Amino-5-benzylideneaminouracils with Diethyl Azodicarboxylate
- The Synthesis and Reactions of Some Isoxazolo [3,4-d] pyrimidines
- Nitrosative Cyclization of 1,3-Dimethyl-6-(α-methylalkylidenehydrazino)-uracils by Means of N-Nitrosodimethylamine-Phosphorus Oxychloride Mixture. A New Route to 2-Vinyl-v-triazolo [4,5-d] pyrimidines
- シメチジン製剤(錠剤・細粒)の品質比較評価
- Synthetic Antibacterials. V. 7-Substituted 1-Ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acids
- The Novel Use of Diethyl Azodicarboxylate in a New Synthesis of 7-Azapteridine-N-oxides
- The N-Oxides of New Heterocyclic Systems. Syntheses and Chemical Properties of Thiazolo [4,5-g] quinazoline 3-Oxides and Thiazolo [5,4-f] quinazoline 3-Oxides
- Synthesis of Nitrogen-containing Cyclic Compounds. CXV. Synthesis of Imidazopyridine Derivatives. (2).
- Synthesis of [1,2,3] Thiadiazolo [5,4-d] pyrimidines
- Oxidative Cyclization of 6-Amino-5-benzylideneamino-1,3-dimethyluracils with Thionyl Chloride. A Convenient Synthesis of 8-Substituted Theophyllines
- ビソルポン液と1%ネオドリンS液との配合変化
- Condensation Reactions of Ethyl Ethoxymethylenecyanoacetate with Amidines
- Synthesis and Properties of 1,3-Dimethyl-6-azalumazines (Isofervenulins)
- A Variant Route to Alloxazines
- Synthetic Antibacterials. II. Synthesis of Pyrido [2,3-d] pyrimidine Derivatives. (1)
- A Novel Synthesis of Iminodipyrimidines
- Syntheses and Properties of Some Pyrrolo[2,3-d]pyrimidine Derivatives
- Dimethylamination and Nitrosation of Pyrimidines with N-Nitrosodimethylamine
- Intermolecular Dimethylamination and Nitrosation with N-Nitrosodimethylamine
- A Novel Synthesis of 6-Deoxytheophyllines and 6-Deoxy-7-deazatheophyllines
- Synthesis of 1,3-Dialkylcytosine Derivatives
- Dimethylamination and Formylation of Pyrimidines with Dimethylformamide
- A Convenient Chlorination of Pyrimidines with Thionyl Chloride
- Uber die Synthese der heterozyklischen Verbindungen mit Stickstoff. CXIV. Die Merkurierung der Oxypyridine.
- Die Synthese der Imidazopyridinderivate.
- Uber das 3,5-Dinitro-2-pyridon.
- Uber die Synthese der heterozyklischen Verbindungen mit Stickstoff. CXIII. Synthese der Azaphenoxazinderivate. (2).
- Uber die Synthese der heterozyklischen Verbindungen mit Stickstoff. CXII. Synthese der Derivate des Oxypyridins.
- Syntheses of Heterocyclic Compounds of Nitrogen. CX. Azaphenoxazine Derivatives.
- Uber die Synthese der heterozyklischen Verbindungen mit Stickstoff. CIII. Die Synthese der Derivate des 3-Oxypyridins (1).
- 含窒素環化合物の合成(第98報)3-ニトロ-4-オキシピリジン並びに3-アミノ-4-オキシピリジンに対するα-ハロゲンケトン類の作用について
- Thio-analogues of 6-Substituted 1,3-Dimethyl-7-azalumazine (Fervenulin) and 7-Substituted 1,3-Dimethyl-6-azalumazine (Isofervenulin)
- The Syntheses of Some Androstano [2,3-g] pteridines
- 1,3,6,8-Tetramethyl-2,4,5,7 (1H, 3H, 6H, 8H) pyrimido [5,4-g] pteridinetetrone and 1,3,5,7-Tetramethyl-2,4,6,8 (1H, 3H, 5H, 7H)-pyrimido [4,5-g] pteridinetetrone
- Oxidation of 5-Nitrosopyrimidines by Nitrous Acid. A Synthesis of 5-Nitropyrimidines